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TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum 
2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress
TranscriptomicsEvolution of virulence control by the staphylococcal agr quorum-sensing regulator
The Staphylococcus aureus accessory gene regulator (agr) is a prototype quorum-sensing system in Gram-positive bacteria and a paradigmatic example of gene regulation by a small regulatory RNA, RNAIII. Using genome-wide transcriptional profiling in the community-associated methicillin-resistant (CA-M...
ORGANISM(S): Staphylococcus aureus 
2010-05-14 | E-GEOD-10165 | biostudies-arrayexpress
TranscriptomicsThe carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence
The purpose of this study was to examine how ethoxzolamide modulates gene M. tuberculosis gene expression at acidic pH. We observed that ethoxzolamide downregulates genes of the PhoPR regulon. Mtb strain CDC1551 was grown at 37C in T-25 vented, standing tissue culture flasks in 8 ml of buffered 7H9 ...
ORGANISM(S): Mycobacterium tuberculosis 
2015-05-20 | E-GEOD-63917 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptococcus agalactiae strains 2603V/R and 515 and CsrR or CsrS isogenic mutants to better understand the CsrRS regulon
CsrRS is a two-component regulatory system that controls expression of multiple genes and affects virulence in group B Streptococcus (GBS), a major cause of neonatal sepsis and of invasive infection in chronically ill adults. To better understand the CsrRS regulon and its importance in GBS pathogen...
ORGANISM(S): Streptococcus agalactiae 
2008-11-25 | E-TIGR-131 | biostudies-arrayexpress
TranscriptomicsIdentification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity
We analyzed a deletion mutant of the ECF M-OM-^C factor SigX and applied mRNA profiling to define the SigX dependent regulon in P. aeruginosa in response to low osmolarity medium conditions. Furthermore, the combination of transcriptional data with chromatin immunoprecipitation (ChIP) followed by hi...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2013-11-11 | E-GEOD-50937 | biostudies-arrayexpress
TranscriptomicsThe RegR virulence regulon of rabbit specific enteropathogenic Escherichia coli strain E22
To investigate the regulatory targets of the RegR virulence regulon of rabbit specific enteropathogenic Escherichia coli strain E22 Single factor (genotype) with dye swaps.
ORGANISM(S): Escherichia coli E22 
2012-12-25 | E-GEOD-41093 | biostudies-arrayexpress
GenomicsThe Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment.
The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment.
PRJNA1365933 | ENA
Transcriptomicss54 -dependent response to nitrogen limitation and virulence in Burkholderia cenocepacia H111
Members of the genus Burkholderia are versatile bacteria capable of colonizing highly diverse environmental niches. In this study, we investigated the global response of the opportunistic pathogen Burkholderia cenocepacia H111 to nitrogen limitation at the transcript and protein expression level. In...
ORGANISM(S): Burkholderia cenocepacia H111 
2015-04-29 | E-GEOD-66328 | biostudies-arrayexpress
TranscriptomicsThe RegR virulence regulon of rabbit specific enteropathogenic Escherichia coli strain E22
To investigate the regulatory targets of the RegR virulence regulon of rabbit specific enteropathogenic Escherichia coli strain E22
ORGANISM(S): Escherichia coli E22 
2012-12-25 | GSE41093 | GEO
UnknownComparative transcriptomics reveals a highly polymorphic Xanthomonas HrpG virulence regulon.
Not available
S-EPMC11316434 | biostudies-literature
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