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MetabolomicsTranscriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates
The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported between species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes could pro...
2022-11-17 | MTBLS5943 | MetaboLights
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
TranscriptomicsSubcutaneous adipose tissue and visceral adipose tissue gene expression profiles in Mexican patients with obesity
Using RNA isolated from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples obtained from control and class I, II and III obese patients undergoing inguinal hernia repair and laparoscopic cholecystectomy, we compared the gene expression profiles between SAT and VAT using micr...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-84599 | biostudies-arrayexpress
ProteomicsThe Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Adipose tissue proteomics
To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic s...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD041721 | Pride
Adipose tissue  visceral adipose tissue  subcutaneous adipose tissue  obesity  proteomics  type 2 diabetes 
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
TranscriptomicsscRNA-seq of stromal vascular cells from 48 week (aged) mouse subcutaneous adipose tissue compared to control 10 week (young) mouse SVF
Adipose tissue mass and adiposity change throughout the lifespan. During aging, while visceral adipose tissue (VAT) tends to increase, peripheral subcutaneous adipose tissue (SAT) decreases significantly. Unlike VAT, which is linked to metabolic diseases, SAT has beneficial effects. However, the mol...
ORGANISM(S): Mus musculus 
2021-03-25 | E-MTAB-10221 | biostudies-arrayexpress
ProteomicsThe Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Serum proteomics
To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic s...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041750 | Pride
Adipose tissue  visceral adipose tissue  subcutaneous adipose tissue  obesity  proteomics  type 2 diabetes  serum proteomics 
TranscriptomicsGene methylation profiles in visceral adipose tissue of obese men with and without the metabolic syndrome
Evaluate differences in gene methylation levels between obese men with and without the metabolic syndrome Visceral adipose tissue from obese men with the metabolic syndrome (MetS+, N=7) vs. obese men without the metabolic syndrome (MetS-, N=7)
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-54776 | biostudies-arrayexpress
TranscriptomicsRainbow trout adipose tissue depots (VAT, SAT, IMAT) - mRNAs
The aim of this study was to characterize different adipose tissue depots in rainbow trout (Oncorhynchus mykiss) through the analysis of mRNA and miRNA expression profiles. Mature adipocytes were isolated from visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissues, and RNA sequ...
ORGANISM(S): Oncorhynchus mykiss 
2026-01-12 | E-MTAB-16058 | biostudies-arrayexpress
ProteomicsHuman recombinant relaxin-2 (serelaxin) regulates the proteome, lipidome, lipid metabolism and inflammatory profile of rat visceral adipose tissue.
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several cardiovascular diseases (CVD). Considering these effects, together with the influence of relaxin-2 on adi...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-23 | PXD048506 | Pride
Lipolysis metabolism Inflammation Serelaxin Lipidome Visceral adipose tissue Proteome 
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