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TranscriptomicsTranscription profiling by array of fibroblasts from eight individuals to evaluate variability in the establishment of induced pluripotent stem cell lines and to develop future cellular models of disease.
Fibroblasts from eight individuals were chosen to evaluate variability in the establishment of iPSC lines and to develop future cellular models of disease. From the eight patients four were healthy controls (Cont) and four were schizophrenic (Sz). All the patients were males with ages ranging from 2...
ORGANISM(S): Homo sapiens 
2012-09-29 | E-MTAB-1040 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human olfactory neurosphere-derived cell lines from healthy and idiopathic Parkinsons disease individuals.
The human olfactory epithelium represents a readily accessible source of adult neural cell types which can be propagated in vitro. We have used this feature to establish olfactory neurosphere-derived (hONS) cells lines from patients with idiopathic Parkinson's disease (PD) and healthy controls. We i...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-TABM-879 | biostudies-arrayexpress
TranscriptomicsRotenone susceptibility phenotype in olfactory derived patient cells as a model of idiopathic Parkinson’s disease
Physiologically relevant cellular models are critical for understanding complex pathological processes. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by motor and non-motor symptoms. Several cellular models for PD have been developed to reproduce the a...
ORGANISM(S): Homo sapiens 
2016-10-04 | E-MTAB-4164 | biostudies-arrayexpress
TranscriptomicsDNA methylation in schizophrenia in different patient-derived cell types
DNA methylation of gene promoter regions represses transcription and is a mechanism via which environmental risk factors could affect cells during development in individuals at risk for schizophrenia. We investigated DNA methylation in patient-derived cells that might shed light on early development...
ORGANISM(S): Homo sapiens 
2017-11-01 | E-MTAB-5016 | biostudies-arrayexpress
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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