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MetabolomicsPost-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor

INTRODUCTION: Application of metabolomic methods to forensic studies may expand the limits of the post-mortem interval (PMI) estimation, and improve the accuracy of the estimation. To this end, it is important to determine which tissue is the most suitable for analysis, and which...

2021-02-02 | MTBLS1518 | MetaboLights
MetabolomicsMetabolomics of the human aqueous humor
Introduction: The optical elements of the eye – cornea, lens, and vitreous humor – are avascular tissues, and their nutrition and waste removal are provided by aqueous humor (AH). The AH production occurs through the active secretion and the passive diffusion/ultrafiltration of blood plasma. The com...
2017-11-06 | MTBLS386 | MetaboLights
MetabolomicsPost-mortem changes in the metabolomic compositions of rabbit blood, aqueous and vitreous humors
Introduction: The analysis of post-mortem metabolomic changes in biological fluids opens the way to develop new methods for the estimation of post-mortem interval (PMI). It may also help in the analysis of disease-induced metabolomic changes in human tissues when the postoperational samples are comp...
2017-08-23 | MTBLS349 | MetaboLights
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
ProteomicsH.sapiens - Cell line, Vitreous humor, SC (Murthy,clin_proteomics,2014)
abundance based on Spectral counting, vitreous_humor, Interaction consistency score: 7.3, Coverage: 4
ORGANISM(S): 9606 
2014-00-00 | 440404448 | PAXDB
ProteomicsProteomic analysis of human vitreous humor
In this study, we investigated the proteome of normal human vitreous humor using high resolution Fourier transform mass spectrometry. We identified 1269 proteins. This largest catalog of vitreous proteins to date should facilitate biomedical research into pathological conditions of the eye including...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD000957 | Pride
Retina Body fluid proteomics Protein biomarkers 
ProteomicsALTERED PATTERN OF PROTEOLYSIS OF EXTRACELLULAR PROTEINS IN RHEGMATOGENOUS RETINAL DETACHMENT BY MINING OF TRYPTIC AND N-TERMINI DATASETS FROM VITREOUS HUMOR PROTEOME
Retinal detachment is a severe eye condition characterized by the detachment of the neurosensory retina from the retinal pigment epithelium and caused by retinal tears. Pars plana vitrectomy is the elective surgical procedure during which vitreous humor, a fluid which shapes the eye globe and suppor...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD057155 | Pride
Eye Vitreous humor Uhplc-ms Ocular fluids Dda 
ProteomicsProtein profile of vitreous from Reeler model
To provide information about candidate factors contributing to impaired retinogenesis that might be useful tool for alternative therapeutic strategies, proinflammatory/profibrogenic mediator were evaluated in the vitreous from Reelin deficient mice, a model characterized by impaired retinogenesis. V...
ORGANISM(S): Mus musculus 
2019-02-13 | E-MTAB-7622 | biostudies-arrayexpress
ProteomicsUveal Melanoma Human Vitreous Proteome
The purpose of the project was to profile protein expression liquid vitreous biopsies from uveal melanoma (UM) patients using mass spectrometry, to identify prognostic biomarkers, signaling pathways, and therapeutic targets. Vitreous biopsies were collected from two cohorts: comparative control eyes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043403 | Pride
Vitreous Uveal melanoma Human 
ProteomicsVitreous Humor Proteomic Profile
Comprehensive proteomic analyses of vitreous humor using liquid chromatography with tandem mass spectrometry were performed in 10 patients with VRL, 10 control patients with idiopathic epiretinal membrane or macular hole, and 10 patients with ocular sarcoidosis.
ORGANISM(S): Homo Sapiens (human) 
2024-10-16 | PXD046153 | JPOST Repository
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