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MetabolomicsPost-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor

INTRODUCTION: Application of metabolomic methods to forensic studies may expand the limits of the post-mortem interval (PMI) estimation, and improve the accuracy of the estimation. To this end, it is important to determine which tissue is the most suitable for analysis, and which...

2021-02-02 | MTBLS1518 | MetaboLights
MetabolomicsPost-mortem changes in the metabolomic compositions of rabbit blood, aqueous and vitreous humors
Introduction: The analysis of post-mortem metabolomic changes in biological fluids opens the way to develop new methods for the estimation of post-mortem interval (PMI). It may also help in the analysis of disease-induced metabolomic changes in human tissues when the postoperational samples are comp...
2017-08-23 | MTBLS349 | MetaboLights
MetabolomicsHuman vitreous amino acid & lipid analysis
Not available
ORGANISM(S): Homo sapiens 
ST000699 | MetabolomicsWorkbench
ProteomicsUveal Melanoma Human Vitreous Proteome
The purpose of the project was to profile protein expression liquid vitreous biopsies from uveal melanoma (UM) patients using mass spectrometry, to identify prognostic biomarkers, signaling pathways, and therapeutic targets. Vitreous biopsies were collected from two cohorts: comparative control eyes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043403 | Pride
Vitreous Uveal melanoma Human 
ProteomicsProtein profile of vitreous from Reeler model
To provide information about candidate factors contributing to impaired retinogenesis that might be useful tool for alternative therapeutic strategies, proinflammatory/profibrogenic mediator were evaluated in the vitreous from Reelin deficient mice, a model characterized by impaired retinogenesis. V...
ORGANISM(S): Mus musculus 
2019-02-13 | E-MTAB-7622 | biostudies-arrayexpress
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
ProteomicsDifferential proteomes in the vitreous of mice with a chronic hypoxic response in photoreceptors
Reduced oxygenation of photoreceptors and the RPE in the ageing eye may be a risk factor for the development of both neovascular and dry AMD. Chronic activation of the molecular response to hypoxia in RPE or photoreceptors leads to retinal degeneration that depends on hypoxia inducible transcription...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-12 | PXD008911 | Pride
Retinal degeneration Vitreous Cones Rods Hypoxic response Amd Shot-gun proteomics 
ProteomicsHuman PDR Vitreous Variability Study, TMT-MS
Control (n=27) and proliferative diabetic retinopathy (n=23) vitreous samples were treated as biologically distinct individuals or pooled together and aliquoted into technical replicates. Quantitative mass spectrometry with tandem mass tag labeling was used to identify proteins in individual or pool...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD025986 | Pride
Proliferative diabetic retinopathy Vitreous Tmt-ms Human 
ProteomicsDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocula...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-09-13 | PXD009525 | Pride
Eye Vitreous Thermogelling polymer Retinal detachment repair Rabbit 
ProteomicsValidation of potential growth-related proteins in chick vitreous during emmetropization using targeted-based proteomics (MRMHR)
The relatively new high-resolution MRM (MRMHR) approach with the Triple-TOF MS running under nanoflow was adopted in this study to solidify further the findings of SWATH-MS results of differentially expressed proteins found across the time points in the chick vitreous for the benefit of low peptide ...
ORGANISM(S): Gallus gallus (Chicken) 
2024-09-25 | PXD056184 | Pride
Vitreous Swath-ms Mrmhr 
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