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TranscriptomicsRNA expression data from glomeruli lacking von Hippel-Lindau protein in podocytes
We and others have previously shown that glomerular endothelial cells and podocytes express hypoxia-inducible transcription factors (HIFs). HIFs bind to hypoxia response elements in target genes, such as vascular endothelial growth factor, which is continually produced by podocytes throughout life....
ORGANISM(S): Mus musculus 
2010-08-03 | E-GEOD-20235 | biostudies-arrayexpress
TranscriptomicsGenetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans
The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated a subunits of hypoxia-inducible factor (HIF). Although studies of VHL defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysr...
ORGANISM(S): Caenorhabditis elegans 
2005-07-20 | E-GEOD-2963 | biostudies-arrayexpress
TranscriptomicsIGR_VHL_GE
VHL is a tumor suppressor gene involved in the oxygen-sensing pathway whose germline mutations predispose to distinct phenotypes. Heterozygous mutations predispose to von Hippel-Lindau disease characterized by the development of multiple tumors (including hemangioblastomas, renal cell carcinomas and...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-MTAB-1269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from mice with constitutively active Hypoxia Inducible Factor (HIF-1a and HIF-2a) or inactivated von Hippel-Lindau tumor suppressor gene product (pVHL)
The effects of constitutively active Hypoxia Inducible Factor (HIF) and inactivated von Hippel-Lindau tumor suppressor gene product (pVHL) were examined in a mouse model. Conditionally expressed, constitutively active HIF-1a and HIF-2a were compared with inactivated pVHL.
ORGANISM(S): Mus musculus 
2006-09-21 | E-MEXP-856 | biostudies-arrayexpress
TranscriptomicsHIF orchestrated metabolic shift confers protection against Acute Kidney Injury (AKI)
Renal hypoxia is widespread in acute kidney injury (AKI) of various aetiologies. Hypoxia adaptation, conferred through the hypoxia-inducible factor (HIF), appears to be insufficient. Here we show that HIF activation in renal tubules through Pax8-rtTA-based inducible knockout of von Hippel-Lindau pro...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-44925 | biostudies-arrayexpress
GenomicsVon Hippel-Lindau syndrome multi-region exome sequencing project from two patients undertaken at Cancer Research UK's London Research Institute
Multi-region whole exome sequencing of tumours from patients with Von Hippel-Lindau syndrome reveals convergence of mutayional events upon the PI3L-AKT-mTOR signalling pathway.
EGAS00001000907 | EGA
TranscriptomicsPleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis and ATM-Mediated DNA Damage Response
Gene expression data from VHL teratomas comparing genes differentially expressed based on apoptotic response to tumor microenvironment. Abstract BACKGROUND: The risk relevance of the P81S von Hippel-Lindau (VHL) gene hotspot mutation identified in clear cell renal cell carcinoma from individuals ex...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-37464 | biostudies-arrayexpress
TranscriptomicsRNA-seq of a VHL-/- human renal cancer cell line 786-0 transfected with 3 vectors
The human renal cancer cell line 786-0 was transfected with 3 vectors allowing the doxycycline-inducible expression of 1) the full length wild type sequence of VHL: 786-0 VHL WT, VHL+/+, 2) the R167Q mutant : 786-0 R167Q, VHL mutated, 3) the empty vector : 786-0 EV, VHL-/-. The aim of the study was ...
ORGANISM(S): Homo sapiens 
2021-12-09 | E-MTAB-11168 | biostudies-arrayexpress
TranscriptomicsPatterns of gene expression and copy-number alterations in VHL disease-associated and sporadic ccRCC
Recent insights into the role of the VHL tumor suppressor gene in hereditary and sporadic clear cell carcinoma of the kidney (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wi...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-14994 | biostudies-arrayexpress
TranscriptomicsRNA expression data from kidneys lacking von Hippel-Lindau (VHL) protein in tubular epithelial cells
The cellular response to low oxygen supply is mediated by hypoxia-inducible factors (HIF). Under hypoxic conditions, HIF is stabilized and target genes are induced. Under normoxia, however, HIF is ubiquitinated through the von Hippel-Lindau protein (VHL), which results in proteasomal degradation. HI...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-54172 | biostudies-arrayexpress
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