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ProteomicsLabel free quantitative mass spectrometry identifies platelet degranulation as an early event during platelet storage
Shelf life of platelet concentrates (PCs) is limited to up to 7 days due to loss of platelet functionality during storage, commonly referred to as the platelet storage lesion (PSL). To get more insight into the development of the PSL, we used label free quantitative mass spectrometry to identify cha...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD005610 | Pride
Proteomics Label free quantification Alpha-granules Platelet storage Platelets 
UnknownFVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4.
Not available
S-EPMC12130761 | biostudies-literature
ProteomicsA red blood cell-based antigen delivery system to facilitate T cell epitope presentation to induce peripheral tolerance to ADAMTS13 in immune-mediated TTP
Aims Leveraging the tolerogenic nature of their natural clearance pathway, we aim to exploit red blood cells (RBCs) as an antigen delivery system to achieve persistent exposure to ADAMTS13-derived peptides, promoting antigen-specific attenuation of autoreactive CD4+ T cells and induction of regulato...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD064980 | Pride
Adamts13 Ittp Immunopeptidomics Antigen presentation 
UnknownComparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells.
Not available
S-EPMC5777204 | biostudies-literature
UnknownThe class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages.
Not available
S-EPMC5744037 | biostudies-literature
UnknownAmelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs.
Not available
S-EPMC11786658 | biostudies-literature
UnknownDeterminants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis.
Not available
S-EPMC9986104 | biostudies-literature
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