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ProteomicsHDX-MS of Immobilized Staph Enterotoxin B with Neutralizing Serum
Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD051156 | Pride
Hdx-ms Serum hdx Seb Immobilized hdx 
ProteomicsHDX of SEB and Neutralizing mAbs
Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD051141 | Pride
Hdx-ms Hydorgen deuterium exchange Seb 
ProteomicsGermline encoded residues dominate the interaction of a human monoclonal antibody with Decorin binding protein A (DbpA) of Borrelia burgdorferi
During the course of Lyme disease, humans mount a robust and sustained antibody response against dozens of Borrelia burgdorferi outer surface lipoproteins. Identifying which antibodies are associated with spirochete clearance and disease resolution is of paramount importance in therapeutic developme...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD062826 | Pride
Monoclonal Borrelia Dbpa Hdx-ms 
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