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TranscriptomicsRole of the extracytoplasmic-function sigma Factor sigmaH in Mycobacterium tuberculosis global gene expression
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-03 | E-GEOD-8689 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis ECF sigma Factor sE: role in global gene expression and survival in macrophages
In previously published work, we identified three Mycobacterium tuberculosis sigma (s) factor genes responding to heat shock (sigB, sigE and sigH ). Two of them (sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the s factors encoded by these genes could be ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-02 | E-GEOD-8664 | biostudies-arrayexpress
TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
TranscriptomicsThe unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, important for anaerobic survival and perhaps latent infection. The individual and collective roles of these sensors has been postulated biochem...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2009-06-26 | E-GEOD-16811 | biostudies-arrayexpress
TranscriptomicsSigma factor B (sigB) response to stress conditions (0.05% SDS and 5mM Diamide)
The numerous sigma factors present in Mycobacterium tuberculosis (MTB) are indicative of adaptability to different environmental conditions. In this report we describe the sigma factor B (sigB) regulon and the phenotypes of a MTB sigB mutant strain exposed to different stresses like SDS and Diamide....
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-25 | E-GEOD-15976 | biostudies-arrayexpress
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type and sigH mutant strains after exposure to the thiol-specific oxidizing agent diamide
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
no omics definedTranscription profiling of Mycobacterium tuberculosis wild type and sigE mutant strains after exposure to stress induced by SDS
In previously published work, we identified three Mycobacterium tuberculosis sigma (s) factor genes responding to heat shock (sigB, sigE and sigH ). Two of them (sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the s factors encoded by these genes could be ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-313 | biostudies-arrayexpress
TranscriptomicsRole of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-08 | E-GEOD-8732 | biostudies-arrayexpress
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