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TranscriptomicsSigma factor B (sigB) response to stress conditions (0.05% SDS and 5mM Diamide)
The numerous sigma factors present in Mycobacterium tuberculosis (MTB) are indicative of adaptability to different environmental conditions. In this report we describe the sigma factor B (sigB) regulon and the phenotypes of a MTB sigB mutant strain exposed to different stresses like SDS and Diamide....
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-25 | E-GEOD-15976 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of a complex phenotype: cord formation in Mycobacterium tuberculosis
Tuberculosis (2004) 84, 188196 (www.elsevierhealth.com/journals/tube),Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis,Qian Gao, Katharine Kripke, Zuhre Arinc, Martin Voskuil, Peter Small
ORGANISM(S): Mycobacterium tuberculosis 
2005-11-03 | E-SMDB-2867 | biostudies-arrayexpress
TranscriptomicsThe response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species
The bacteriostatic and bactericidal effects and the corresponding expression profiles of Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were investigated by growth and survival studies and whole genome expression analysis. The response of M. tuberculosis to a range ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-16146 | biostudies-arrayexpress
TranscriptomicsThe unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, important for anaerobic survival and perhaps latent infection. The individual and collective roles of these sensors has been postulated biochem...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2009-06-26 | E-GEOD-16811 | biostudies-arrayexpress
Transcriptomics24 Hour Response of M. tuberculosis Erdman TMCC 107 to 20 micromolar clofazimine
3 sets of CFZ-exposed bacteria were compared to 3 sets of bacteria treated with vehicle (DMSO) for 24 hours in an aerated drug killing model.
ORGANISM(S): Mycobacterium tuberculosis 
2020-07-22 | E-MTAB-9350 | biostudies-arrayexpress
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis to study stationary phase and dormancy gene expression
The innate mechanisms used by Mycobacterium tuberculosis to persist during periods of non-proliferation are central to understanding the physiology of the bacilli during latent disease. We have used whole genome expression profiling to expose adaptive mechanisms initiated by M. tuberculosis in two c...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-24 | E-SMDB-4101 | biostudies-arrayexpress
TranscriptomicsBCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy
Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease that affects one-third of the world’s population. The sole extant vaccine for tuberculosis is the live attenuated Mycobacterium bovis bacille Calmette-Guerin (BCG). We examined 13 representative BCG strains from around the ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2008-05-03 | E-GEOD-11315 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type and Rv3133c/DosR mutants grown in hypoxic conditions
Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state. Latency is often linked to hypoxic conditions within the host. Among M. tuberculosis genes induced by hypoxia is a putative transcription factor...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-29 | E-SMDB-4099 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis treated with nitric oxide to investigate the effect on latency
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-29 | E-SMDB-4062 | biostudies-arrayexpress
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