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TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44266 | biostudies-arrayexpress
ProteomicsStructural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
crosslinking mass spectrometry results for sulfo-SDA crosslinking of human CUL4-NEDD8/ROC1/DDB1/DCAF1-CtD in complex with SAMHD1 and Vpr protein from simian immunodeficiency virus infecting Cercopithecus cephus (SIVmus Vpr)
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD020453 | Pride
Human cullin vpr crosslinking 
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
ProteomicsMassive Proteome Remodelling by HIV Vpr
Viruses target host proteins for degradation to enhance their replication and transmission, and identifying these targets has provided key insights into the host-pathogen interaction1-3. Here, we use complementary unbiased mass spectrometry-based approaches to dissect the widespread proteomeic remod...
ORGANISM(S): Homo sapiens (Human) 
2019-05-01 | PXD013221 | Pride
Hiv Tmt Vpr 
GenomicsTranscriptomic analysis of Pepck-Vpr mouse kidney
Transcriptomic analysis of Pepck-Vpr mouse kidney
PRJNA928355 | ENA
TranscriptomicsTranscription profiling by array of human CD4+ T-lymphocytes infected with VSVG-pseudotyped HIV-1 viruses lacking Env, Vpr, and Nef
The high mutation rate of HIV is linked to the generation of viruses expressing proteins with altered function whose impact on disease progression is unknown. We investigated the effects of HIV-1 viruses lacking Env, Vpr and Nef on CD4+ T cell gene expression using high-density DNA microarray analys...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12963 | biostudies-arrayexpress
TranscriptomicsExpression data from human monocyte derived macrophages infected with adenovirus expressing HIV-1 Vpr
HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune respone and...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-56591 | biostudies-arrayexpress
TranscriptomicsExpression data from human monocyte derived dendritic cells infected with adenovirus expressing HIV-1 Vpr
HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune responses. ...
ORGANISM(S): Homo sapiens 
2014-09-06 | E-GEOD-61171 | biostudies-arrayexpress
TranscriptomicsMolecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr
Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders [differentiated SH-5Y cells]
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-43535 | biostudies-arrayexpress
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