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UnknownComparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance.
Not available
S-EPMC5449500 | biostudies-literature
UnknownLRRC8/VRAC volume-regulated anion channels are crucial for hearing.
Not available
S-EPMC11260850 | biostudies-literature
UnknownLRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT).
Not available
S-EPMC6895240 | biostudies-literature
UnknownRenal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.
Not available
S-EPMC9342636 | biostudies-literature
UnknownThe CaMKII/MLC1 Axis Confers Ca2+-Dependence to Volume-Regulated Anion Channels (VRAC) in Astrocytes.
Not available
S-EPMC9454758 | biostudies-literature
ProteomicsViruses antagonise expression and function of cGAMP transporters, channels and pores
DNA sensing is a fundamental process in the immune system, including host defence against viruses. The DNA sensor cGAS synthesises 2’3’ cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which subsequently induces innate immunity. cGAMP not only activates STING in the cell where it is ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-15 | PXD043229 | Pride
Na sensing  cgamp  cgamp transport  vrac  lrrc8a  slc46a2  p2x7  herpes simplex virus  ul56 
ProteomicsCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and transports halide anions and small organic compounds. Despite the recent a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD018780 | Pride
Lrrc8d 
UnknownLeucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.
Not available
S-EPMC6170198 | biostudies-literature
ProteomicsMLC phosphorylation by the kinase CaMKII
MLC1 is membrane protein highly expressed by brain perivascular astrocytes. Mutations in MLC1 account for megalencephalic leukoencephalopathy with subcortical cysts (MLC), an incurable leu-kodystrophy characterized by macrocephaly, brain edema and cysts, myelin vacuolation and as-trocyte swelling, t...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD030549 | Pride
Mlc megalencephalic leukoencephalopathy phosphorylation mass spectrometry 
UnknownSyringin inhibits endogenous volume regulated anion channel currents of HEK293 cells in hypotonic circumstances.
Not available
S-EPMC10242655 | biostudies-literature
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