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TranscriptomicsA fraction of steady state splenic XCR1+ dendritic cells undergo an homeostatic maturation as assessed by their upregulation of CCR7 or of IL-12, and by their profound genetic reprogramming
XCR1+ dendritic cells (DC) have been shown to excel in antigen cross-presentation for the activation of naïve CD8 T cells. This property was reported to be associated to the subset of the XCR1+ DC expressing IL-12b upon ex vivo stimulation for 24 h with a mixture of CpG, IFN-γ, and GM-CSF (Lin ML ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71167 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression study of the early/innate responses of murine B and T cells to MCMV infection
Murine Cytomegalovirus (MCMV) infection leads to early activation of various immune cells, including B and T lymphocytes, before the actual initiation of antigen-specific adaptive immunity. This activation is partly driven by innate cytokines, including type I interferon (IFN), which are induced ear...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-45365 | biostudies-arrayexpress
UnknownA 128-channel receive array for cortical brain imaging at 7 T.
Not available
S-EPMC10543549 | biostudies-literature
TranscriptomicsGene expression of T follicular helper (TFH) cells 6 h after ICOS-L blockade
The maintenance of the TFH phenotype depends on continuous signals via ICOS. For a global assessment of differences in gene expression after interruption of the ICOS pathway a genome wide transcriptome analysis was performed. We used the OT-II adoptive transfer system to isolate antigen-specific TFH...
ORGANISM(S): Mus musculus 
2015-01-19 | E-GEOD-49314 | biostudies-arrayexpress
ProteomicsAuxin-triggered changes in the Arabidopsis root tip (phospho)proteome reveal novel root growth regulators
Canonical auxin signalling starts with auxin binding to the receptor complex, followed by modulation of gene transcription and protein abundance (Tan et al., 2007; Chapman and Estelle, 2009; Slade et al., 2017). However, recent studies also showed an alternative mechanism in roots involving intra-ce...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-09 | PXD021267 | Pride
Auxin Phosphoproteomoics Plant 
MetabolomicsSynergistic metabolism of salivary MUC5B in oral commensal bacteria during early biofilm formation

Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...

2023-10-30 | MTBLS8370 | MetaboLights
UnknownDaratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.
Not available
S-EPMC4957162 | biostudies-literature
UnknownAdoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Not available
S-EPMC5065388 | biostudies-literature
UnknownInjury markers predict time to dementia in subjects with MCI and amyloid pathology.
Not available
S-EPMC3475623 | biostudies-literature
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39873 | biostudies-arrayexpress
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