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ProteomicsProtein content of extracellular vesicles from human brain microvascular endothelial cells treated by paraquat
Since the last decade, the field of extracellular vesicles (EVs) has increasingly grown. These “intracellular messengers” became interesting as biomarker source in the SNC research, because of their content, which may reflect the physiological state of their donor cells in a context of an external s...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024691 | Pride
Endothelia cells Proteomics Extracellular vesicles Dia-ms Paraquat Cns Ubiquinone metabolism Hif-1 Bbb 
ProteomicsOxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells
Morphine, a commonly used antinociceptive drug in hospitals, is known to cross the blood-brain barrier (BBB) by first passing through brain endothelial cells. Despite its pain-relieving effect, morphine also has detrimental effects, such as the potential induction of redox imbalance in the brain. Ho...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038516 | Pride
Extracellular vesicles  endothelial cells  morphine  cns  bbb  proteomics  dia-ms  oxidative stress  hif-1  cell adhesion  extracellular matrix remodeling 
ProteomicsDigoxin induces astrocyte activation into a human in vitro astrocyte model
In this study we have evaluated the effect of digoxin in human astrocytes. Our results have shown that non-cytotoxic concentration of digoxin is able to induce astrocytes activation, by affecting cytoskeleton proteins, increasing the expression of pro-inflammatory genes and altering energy metabolis...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029370 | Pride
Neurotoxicty Astrocytes Neuroinflammation Energy metabolism Astrogliosis Glycolysis 
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