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UnknownEvidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women.

Importance

A recently published study of national data by McGrath et al in 2014 showed increased risk of schizophrenia (SCZ) in offspring associated with both early and delayed parental age, consistent with a U-shaped relationship. However, it remains unclear if the risk to the child is due ...
S-EPMC5785705 | biostudies-literature
UnknownA high-stringency blueprint of the human proteome.
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established ...
S-EPMC7568584 | biostudies-literature
UnknownGene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of d...
S-EPMC7034316 | biostudies-literature
UnknownAnalysis of shared heritability in common disorders of the brain.
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and ...
S-EPMC6097237 | biostudies-literature
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patie...
S-EPMC10208981 | biostudies-literature
UnknownComplement genes contribute sex-biased vulnerability in diverse disorders.
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men1, whereas schizophrenia affects men with greater fre...
S-EPMC7319891 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 popu...
S-EPMC11320601 | biostudies-literature
UnknownContribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to...
S-EPMC5737772 | biostudies-literature
UnknownMapping genomic loci implicates genes and synaptic biology in schizophrenia.
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genom...
S-EPMC9392466 | biostudies-literature
UnknownMinimal manifestation status and prednisone withdrawal in the MGTX trial.

Objective

To examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized patients with myasthenia gravis (MG).

Methods

This study is a post hoc analysis of data from a randomized trial of thymectomy in MG (Thy...
S-EPMC7455358 | biostudies-literature
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