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TranscriptomicsComparison of exosomal and cellular miRNA from patients with chronic lymphocytic leukaemia
Exosomes are secreted into the intercellular space and carry a diverse cargo of proteins, mRNA and miRNA that have important roles in cell-to-cell communication. We found that exosomes from primary human leukaemic B-cells contain a population of miRNAs that has been selected from the general cellula...
ORGANISM(S): Homo sapiens 
2014-07-25 | E-GEOD-54434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mesenchymal Stem Cells (MSC) vs reference RNA of non-multipotent human fibroblasts HS68
Mesenchymal stem cells (MSC) resemble a multipotent adult stem cell population capable of differentiation into a number of different mesodermal cell types including adipodytes, osteoblasts, chondroblasts. Although still in debate there is some evidence, that these cells can also differentiate into c...
ORGANISM(S): Homo sapiens 
2005-08-23 | E-EMBL-4 | biostudies-arrayexpress
TranscriptomicsA single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
We utilize single-cell sequencing (scSeq) of lymphocyte immune repertoires and transcriptomes to quantitatively profile the adaptive immune response in COVID-19 patients of varying age. Our scSeq analysis defines the adaptive immune repertoire and transcriptome in convalescent COVID-19 patients and ...
ORGANISM(S): Homo sapiens 
2021-03-20 | E-MTAB-10169 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gene expression profiles of CD34+/CD38- cells vs AFT024
It is widely accepted that hematopoietic progenitor cells (HPC) are tightly associated with discrete niches within the bone marrow. This molecular environment supports and regulates their self renewal and differentiation. AFT024 is a cell line derived from murine fetal liver that has been demonstrat...
ORGANISM(S): Mus musculus 
2005-06-13 | E-EMBL-3 | biostudies-arrayexpress
TranscriptomicsLong-term culture associated gene expression changes in MSC (TGFb treatment)
Mesenchymal stromal cells (MSC) were isolated from human bone marrow. Here, we have compared gene expression profiles of MSC at early and late passages and upon stimulation with transforming growth factor beta 1 (TGF-b1). Stimulation was performed with 1ng/mL TGF-b1 for 1, 4, or 12 hours as indicate...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-46019 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD34+CD38- vs CD34+CD38+ fractions of human umbilical cord blood and comparison of slow-dividing fraction vs the fast dividing fraction of CD34+/CD38- population
Comparison of the CD34+CD38- versus CD34+CD38+ fractions of human umbilical cord blood and comparison of the slow-dividing fraction versus the fast dividing fraction of the CD34+/CD38- population.
ORGANISM(S): Homo sapiens 
2005-09-08 | E-EMBL-1 | biostudies-arrayexpress
UnknownDiverse Anti-Tumor Immune Potential Driven by Individual IFNα Subtypes.
Not available
S-EPMC7145903 | biostudies-literature
TranscriptomicsTunable protein synthesis by transcript isoforms in human cells (Transcript Isoforms in Polysomes sequencing: TrIP-seq)
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profil...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69352 | biostudies-arrayexpress
UnknownSafety and immunogenicity of a vero cell culture-derived whole-virus H5N1 influenza vaccine in chronically ill and immunocompromised patients.
Not available
S-EPMC4054238 | biostudies-literature
TranscriptomicsKnockdown of Yap1 and Wwtr1 in normal and fibrotic murine alveolar type II cells
Yap1 and Wwtr1 were knocked down via siRNA in primary murine alveolar cells derived from normal or fibrotic mice (PBS treated as a control for bleomycin instilled animals, harvested at 14 days). Isolated cells from three independent isolations were plated on tissue culture plates and allowed to adhe...
ORGANISM(S): Mus musculus 
2025-01-06 | E-MTAB-14643 | biostudies-arrayexpress
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