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TranscriptomicsMethylation Pattern of Human Mesenchymal Stromal Cells
In this study, we have analyzed DNA methylation changes upon long-term culture and aging of MSC by using the HumanMethylation27 BeadChip assessing 27,578 unique CpG sites. Cells were taken from bone marrow aspirates from iliac crest (BM) of healthy donors or from the caput femoris (HIP) of elderly p...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17448 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli
This SuperSeries is composed of the following subset Series: GSE39928: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM] GSE39929: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM] GSE39930: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM] GSE39931: Muri...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39932 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39928 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39930 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39929 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [43MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39931 | biostudies-arrayexpress
ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
TranscriptomicsIn vitro effect of the integrine LAMA4 on motility and cluster formation of human chondrocytes
Background: Cluster formation of hypertrophic chondrocytes is a sign of late stage osteoarthritis. In vitro chondrocytes have the ability to migrate on scaffolds. Important for motility issues in cartilage are integrines, part of the extracellular matrix, important for locomotory stimuli. The integr...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-68428 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging
To determine gene expression changes during in vitro senescence of MSC we have analyzed differential expression of the corresponding early passage (P2) and senescent passage (PX). There were global changes in the gene expression profile that were reproducible in three independent donor samples. Expe...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9593 | biostudies-arrayexpress
TranscriptomicsLoss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factor STAT5. As pregnancy progresses mammary signature genes are activated in a defined temporal order, which coincides with the recruitment of STAT5 to respective regulatory ...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-70440 | biostudies-arrayexpress
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