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TranscriptomicsmRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer
The intention was to detect genes that are determining trastuzumab efficiency in HER2-positive breast cancer cell lines with different resistance phenotypes. While BT474 should be sensitive to the drug treatment, HCC1954 is expected to be resistant due to a PI3K mutation. The cell line BTR50 has bee...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-55005 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for different passages of mesenchymal stem cells.
Cells in culture undergo replicative senescence and unequivocally stop proliferation after a limited number of cell divisions. In this study, we have expanded mesenchymal stem cells (MSC) from human adipose tissue and analyzed genetic and epigenetic sequels. The subpopulation of highly proliferative...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-27135 | biostudies-arrayexpress
UnknownCombined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium.
Not available
S-EPMC10850948 | biostudies-literature
GenomicsEpigen-Brasil - samples
Epigen-Brasil samples using HumanOmni2.5
EGAD00010000787 | EGA
GenomicsGenomic Epidemiology of Complex Diseases in Population-based Brazilian Cohorts
The EPIGEN-Brasil Initiative is so far the largest Latin American initiative in population genomics and genetic epidemiology. Its main goal is to study the association between genetic variants found in the Brazilian population and complex diseases, taking into account one of the most important chara...
EGAS00001001245 | EGA
GenomicsEPIGEN-Brasil Data Access Committee
Data Access Committee EGAC00001000330
EGAC00001000330 | EGA
UnknownThe sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.
Not available
S-EPMC4660783 | biostudies-literature
Genomics5-hydroxymethylcytosine dynamics during retinal maturation
Ten-eleven translocation (Tet) hydroxylases (Tet1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). In neurons increased 5hmC levels within gene bodies correlate positively with gene expression. Here, we studied 5hmC profiles (hMeDIP) during retinal maturation between postnatal we...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-65860 | biostudies-arrayexpress
GenomicsAncient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy
A major challenge in biology is to determine how evolutionarily novel characters originate, however, mechanistic explanations for the origin of novelties are almost completely unknown. The evolution of mammalianM-BM- pregnancy is an excellent system in which to study the origin of novelties because ...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-61793 | biostudies-arrayexpress
UnknownCentral corneal thickness in children.
Not available
S-EPMC3253021 | biostudies-literature
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