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TranscriptomicsTranscription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging
To determine gene expression changes during in vitro senescence of MSC we have analyzed differential expression of the corresponding early passage (P2) and senescent passage (PX). There were global changes in the gene expression profile that were reproducible in three independent donor samples. Expe...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9593 | biostudies-arrayexpress
ProteomicsIdentification of SENP3 and SENP5 target proteins by endogenous SUMO2/3 IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037793 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsIdentification of SENP5 target proteins by endogenous SUMO2/3 IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037796 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsIdentification of UTP14A interactors by endogenous UTP14A IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD043556 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsWhole cell proteome of U2OS cells or Saos-2 cells depleted for SENP3
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037800 | Pride
Sumo Human Senp Lc-ms/ms 
UnknownHemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance.
Not available
S-EPMC8165974 | biostudies-literature
TranscriptomicsTranscription profiling of zebrafish embryos injected with a morpholino targeting LIN9
TÜAB zebrafish were maintained at 28.5 °C in in 1x Danieau solution (58 mM NaCl, 0.7 mM KCl, 0.4 mM MgSO4, 0.6 mM Ca (NO3)2, 5 mM HEPES, pH 7.6, 0.0001 % Methylene blue). Morpholinos (Gene Tools, Philomath, OR) were designed against Danio rerio lin-9 homolog (Genebank accession NM_001044946). The mo...
ORGANISM(S): Danio rerio 
2009-03-28 | E-MEXP-2100 | biostudies-arrayexpress
UnknownUntangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.
Not available
S-EPMC3986492 | biostudies-literature
TranscriptomicsMurine hepatocellular carcinoma of AlbLTa/b transgenic mice and age matched C57BL/6 mice - 18 months old.
aCGH analysis of murine transgenic liver tissues affected with HCC, hybridized with age (18 months) and sex matched C57BL/6 mice. Moreover, 18months old C57BL/6 livers were hybridized with independent 18 months old C57BL/6 livers for control. Keywords: Array comparative genomic hybridization analy...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-14467 | biostudies-arrayexpress
UnknownReproducibility and discrimination of different indices of insulin sensitivity and insulin secretion.
Not available
S-EPMC8549015 | biostudies-literature
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