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ProteomicsStructures reveal DnaA domain I dimer conserved across Actinomycetes: implications for replication initiation
DNA replication is a fundamental process in biology with initiation marking its key, first step. In bacteria, DNA replication is initiated by the DnaA protein. DnaA exhibits multidomain architecture, consisting of an N-terminal domain I, linker region, AAA+ family ATPase cassette, and C-terminal DN...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD074705 | Pride
Hdx ms  dnaa  dimerization  dna replication  dimeric interface  hydrogen/deuterium exchange mass spectrometry 
ProteomicsMolecular mechanism of ssDNA-mediated allosteric activation of the WYL-domain containing transcription regulator, DriD
WYL domain containing transcription factors play critical roles in regulating fundamental processes in bacterial physiology. The Caulobacter crescentus DriD protein is a WYL transcription regulator recently shown to activate a DNA damage response pathway that is independent of the major bacterial SO...
ORGANISM(S): Caulobacter phage CcrColossus 
2025-04-14 | PXD056334 | Pride
Drid  transcription regulator hdx-ms  wyl domain  hydrogen/deuterium exchange mass spectrometry 
ProteomicsConformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
Full-length BTK has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3-SH2-kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and the long linker that includes proline-rich ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041657 | Pride
Btk  hdx-ms  hydrogen/deuterium exchange mass spectrometry 
ProteomicsMagnesium as a Conformational Gatekeeper of KRAS: Structural Dynamics and Therapeutic Implications
Magnesium serves as an essential cofactor for small GTPases, yet its structural role in regulating KRAS conformational dynamics and nucleotide exchange remains poorly understood. Here, we combine hydrogen–deuterium exchange mass spectrometry (HDX-MS), native mass spectrometry, and functional assays ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074470 | Pride
Kras  allostery  hdx-ms  hydrogen/deuterium exchange mass spectrometry 
ProteomicsDynamic conformational equilibria in the active states of KRas and NRas
The design of potent RAS inhibitors benefits from a molecular understanding of the dynamics in KRAS and NRAS and their oncogenic mutants. Here we characterize switch-1 dynamics in GTP-state KRAS and NRAS by 31P NMR, by 15N relaxation dispersion NMR, hydrogen-deuterium exchange mass spectrometry (HDX...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054924 | Pride
Ras inhibitors  nras  kras  hdx-ms  hydrogen/deuterium exchange mass spectrometry  oncogenic mutants 
ProteomicsConformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis
Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of monoclonal light chain (LC) and its fragments containing variable (VL) and portions of constant (CL) domains. AL patients feature either monoclonal free LCs circulating as covalent and noncovalent h...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD055570 | Pride
Igg  amyloid light chain hdx-ms  al amyloidosis  hydrogen/deuterium exchange mass spectrometry 
ProteomicsA druggable redox switch on SHP1 controls macrophage inflammation
Immunological proteins are major disease targets and the majority remain undrugged. Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation, especially in the context of the macrophage cytokine response.1 Here, we develop a strategy for syst...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD055006 | Pride
Shp-1  hdx-ms  hydrogen/deuterium exchange mass spectrometry  covalent activator 
UnknownPathogenic copy number variants and SCN1A mutations in patients with intellectual disability and childhood-onset epilepsy.
Not available
S-EPMC4845474 | biostudies-literature
UnknownA single introduction of wild rabbits triggered the biological invasion of Australia.
Not available
S-EPMC9436340 | biostudies-literature
UnknownOutpatient hospital attendances in people with rheumatoid arthritis during the COVID-19 pandemic and beyond: a cohort study in three nations of the UK.
Not available
S-EPMC12862379 | biostudies-literature
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