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ProteomicsMolecular mechanism of ssDNA-mediated allosteric activation of the WYL-domain containing transcription regulator, DriD
WYL domain containing transcription factors play critical roles in regulating fundamental processes in bacterial physiology. The Caulobacter crescentus DriD protein is a WYL transcription regulator recently shown to activate a DNA damage response pathway that is independent of the major bacterial SO...
ORGANISM(S): Caulobacter phage CcrColossus 
2025-04-14 | PXD056334 | Pride
Drid  transcription regulator hdx-ms  wyl domain  hydrogen/deuterium exchange mass spectrometry 
ProteomicsAllosteric activation mechanism of DriD, a WYL-domain containing transcription regulator
This project aims to understand the ssDNA-mediated allosteric activation mechanism of DriD, a novel Caulobacter crescentus transcription activator. Using LC-MS/MS, the major proteolytic cleavage site within DriD was identified, providing insight into its solvent accessible regions.
ORGANISM(S): Caulobacter vibrioides 
2025-04-14 | PXD062430 | Pride
Lc-ms/ms Drid Caulobacter crescentus Transcription activator 
UnknownAllosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.
Not available
S-EPMC12041258 | biostudies-literature
GenomicsssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD
DNA damage repair systems are critical for genomic integrity. However, they must be coordinated with DNA replication and cell division to ensure accurate genomic transmission. In most bacteria this coordination is mediated by the SOS response through LexA , which triggers a halt in cell division unt...
ORGANISM(S): Caulobacter vibrioides 
2022-05-15 | GSE197978 | GEO
GenomicsssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD
PRJNA813223 | ENA
UnknownssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD.
Not available
S-EPMC9186387 | biostudies-literature
UnknownStructure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site.
Not available
S-EPMC10853764 | biostudies-literature
UnknownExecutive functions and classroom quality in kindergarten predict peer acceptance in first grade.
Not available
S-EPMC12770537 | biostudies-literature
UnknownSchool-Based Intervention Programs for Preventing Obesity and Promoting Physical Activity and Fitness: A Systematic Review.
Not available
S-EPMC6981629 | biostudies-literature
UnknownPhysicochemical and structural properties of lidocaine-based ionic liquids with anti-inflammatory anions.
Not available
S-EPMC9051649 | biostudies-literature
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