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TranscriptomicsNLRC5 is a transcriptional regulator of MHC class I genes
NLRC5 is a member of the NLR family of proteins. The observation that NLRC5 is found in the nucleus prompted us to perform a gene array to identify putative target genes of NLRC5. We generated Jurkat T cell lines that stably express either the wild-type or mutant forms of NLRC5 harboring mutations i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22064 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes analysis between Eupolyphaga sinensis Walker (ESW) and Taspine derivate
To gain insights into the mechanisms of Eupolyphaga sinensis Walker (ESW) and taspine derivate on inhibition to HCC, we have employed whole genome microarray expression profiling as a discovery platform to identify different genes between ESW-treated sample and control. At the same time, the differe...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-52554 | biostudies-arrayexpress
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
TranscriptomicsCXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AHR signaling
Targeting the estrogen signaling pathway has proved to be of great value in the treatment of human breast cancer. Tamoxifen, a selective estrogen receptor modulator (SERM), is the most widely used antiestrogen. However, only 40-50% of patients with estrogen receptor (ER) positive breast cancer benef...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-31831 | biostudies-arrayexpress
TranscriptomicsAnalysis of the impact of extracellular acidosis on the expression of miRNAs in experimental tumor lines LLC-WRC 256 and R-3327-AT-1 of the rat
Hypoxia has been shown to regulate the miRNA expression in tumors. Since many tumors show a extracellular acidosis the aim of the study was to analyze whether the extracellular pH has an impact on the miRNA expression in experimental tumor cells of the rat. Therefore R3327-AT1 Dunning prostate carci...
ORGANISM(S): Rattus norvegicus 
2023-11-29 | E-MTAB-6600 | biostudies-arrayexpress
UnknownNovel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
Not available
S-EPMC11141336 | biostudies-literature
MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
TranscriptomicsTranscription profiling by array of Aedes aegypti infected with Wolbachia strains wMelPop and wMel
Wolbachia is a vertically transmitted intracellular bacteria that infect most than 60% of insect species. The strains wMelPop and wMel were introduced in the dengue virus vector Aedes aegypti, naturally not infected by Wolbachia. Recently, it was shown that those two strains inhibit dengue virus rep...
ORGANISM(S): Aedes aegypti 
2012-01-01 | E-MEXP-2931 | biostudies-arrayexpress
UnknownExome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndrome.
Not available
S-EPMC3512000 | biostudies-literature
TranscriptomicsThe transcriptomic basis of oviposition behaviour in the parasitoid wasp Nasonia vitripennis
For many behaviours studied at the phenotypic level, we have little or no idea of where to start searching for “candidate” genes: the transcriptome provides such a starting point. Here we consider transcriptomic changes associated with oviposition in the parasitoid wasp Nasonia vitripennis. Oviposit...
ORGANISM(S): Nasonia vitripennis 
2013-07-22 | E-GEOD-43352 | biostudies-arrayexpress
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