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MetabolomicsPuerarin Combined with Hericium Erinaceus Insoluble Dietary Fiber Alleviate Obesity Induced by High-fat Diet Through Regulating the Glycerophospholipid Metabolism Pathway Influenced by Gut Microbiota
The combination of HEIDF and Pue holds significant importance in the context of obesity. This synergistic effect not only aids in weight management but may also enhance metabolic health through various mechanisms, including increased satiety and promotion of fat oxidation. Therefore, incorporating t...
2025-02-17 | MTBLS12195 | MetaboLights
MetabolomicsLimosilactobacillus reuteri with indole-3-lactic acid-producing capacity protects against atherosclerosis by fortifying the gut-vascular barrier

Introduction: The gut microbiota and its metabolites are implicated in atherosclerosis, but the specific effector molecules and their pathophysiological significance remain unclear.

Objectives: This study aimed to identify key atheroprotective microbial metabolites and to elucidate the mech...

2026-01-31 | MTBLS13620 | MetaboLights
MetabolomicsFecal metabolomic study in patients with choledocholithiasis concurrent with cholangitis

Metabolites associated with the gut microbiota play an important role in the pathogenesis of choledocholithiasis concurrent with cholangitis (CC). This study aims to characterize the fecal metabolite profile of CC patients and to investigate the correlation and balance within the gut cross-domain...

2025-08-11 | MTBLS12772 | MetaboLights
UnknownMicropeptide CIP2A-BP encoded by LINC00665 inhibits triple negative breast cancer progression
Not available
S-SCDT-EMBOJ-2019-102190 | biostudies-other
ProteomicsLens Disulfide crosslink
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-07-20 | MSV000079952 | MassIVE
ProteomicsTDRD6 IP-MS data in mouse testis protein lysates
We immunoprecipitated endogenous TDRD6 from testis protein lysates of 28-day-old wild-type mice using our home-made TDRD6 antiserum. No TDRD6 protein was identified in Tdrd6-mutant mice carrying the p.G615X (GGG to TGA) variant. Thus, Tdrd6-mutant mice were utilized as negative control. A high-throu...
ORGANISM(S): Mus Musculus 
2023-05-11 | PXD042162 |
ProteomicsLysine methylation promotes NFAT5 activation upon EGFR activation and predicts response to temozolomide
Temozolomide (TMZ) therapy offers minimal clinical benefits in patients with glioblastoma multiforme (GBM) with high EGFR activity, underscoring the need for effective combination therapy. Here, we show that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, is a determinant of...
ORGANISM(S): Homo Sapiens 
2022-11-01 | PXD037869 |
ProteomicsProteomics of cardiac tissue of mice after sepsis model
Dysregulated cardiac function after sepsis is common in intensive care unit (ICU) and known to predict poor long-term outcome and increase mortality. Effective therapeutic strategies are largely lacking. Moreover, the pathological feature and the molecular mechanism underlying cardiac dysfunction in...
ORGANISM(S): Mus Musculus 
2023-04-14 | PXD041530 |
TranscriptomicsT lymphocytes from Chronic HCV-infected patients express unique pro-apoptotic gene signature.
Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic hepatitis C virus (HCV) infection, the transcriptional profiles of global CD4+ and CD8+ T-cells remains unclear. In this report, we recruited 10 long-term (~20 years) tr...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-49954 | biostudies-arrayexpress
ProteomicsPhysical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice
This project focus on the proteomic changes in AD model mice. AD model mice were established by injecting Aβ₄₂ oligomers into the hippocampus. These mice were then subjected to treadmill training(ADE), 40 Hz audio-visual stimulation(ADVL), or a combination of these interventions(ADEVL). Quantitative...
ORGANISM(S): Mus Musculus 
2026-04-27 | PXD077685 |
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