Sort   by:  
 Page size 
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsHybrid Mimics and Hybrid Vigor in Arabidopsis (F6 data)
F1 hybrids can outperform their parents in yield and vegetative biomass, features of hybrid vigor which form the basis of the hybrid seed industry. The yield advantage of the F1 is lost in the F2 and subsequent generations. In Arabidopsis, from F2 plants which have a F1 –like phenotype, we have ...
ORGANISM(S): Arabidopsis thaliana 
2015-08-17 | E-GEOD-64742 | biostudies-arrayexpress
TranscriptomicsHybrid Mimics and Hybrid Vigor in Arabidopsis (F4 data)
F1 hybrids can outperform their parents in yield and vegetative biomass, features of hybrid vigor which form the basis of the hybrid seed industry. The yield advantage of the F1 is lost in the F2 and subsequent generations. In Arabidopsis, from F2 plants which have a F1€“like phenotype, we have by...
ORGANISM(S): Arabidopsis thaliana 
2015-08-17 | E-GEOD-64740 | biostudies-arrayexpress
UnknownDeterminants of breastfeeding self-efficacy among postpartum women in rural China: A cross-sectional study.
Not available
S-EPMC8989199 | biostudies-literature
GenomicsBAF250a regulates nucleosome occupancy and histone modification in priming embryonic stem cell differentiation
BAF complex is one major group of chromatin remodeling factors in mammals. However, how BAF regulated nucleosomes and other histone modifications is not clear. Here we delete BAF250a, a major component in esBAF to study the nucleosome and histone changes in ESCs. We find that deletion of BAF250a lea...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-59082 | biostudies-arrayexpress
ProteomicsASCL1: a pioneer factor that induces subtype switching and characterizes adrenergic neuroblastoma
Neuroblastoma is an embryonic malignancy originating from early nerve cells. Neuroblastoma retains plasticity, interconverting between the mesenchymal (MES) and adrenergic (ADRN) states, which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-12-08 | PXD037670 | Pride
Ascl1 Subtype switching Neuroblastoma Pioneer factor Core regulatory circuit 
ProteomicsMELK mediates the stability of EZH2 throught site-specific phosphorylation in extranodal natural killer/T-cell lymphoma
Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we exam...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD015008 | Pride
Melk Silac Ubiquitination Phosphorylation Extranodal natural killer/t-cell lymphoma (nktl) Ezh2 
ProteomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression
CIITA is the master regulator of MHC II genes expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and by pIV, and can also be induced by IFNg in non-immune cells. While key regulatory elements have been iden...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD043134 | Pride
Mhc ii Adaptive immunity B cell Zinc finger Pioneer factor Molecular switch Ciita Zbtb48 
ProteomicsSecretory autophagy mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents an important mechanism in mitochondrial quality control (MQC) via clearance of damaged mitochondria. Although it is well known that the conjugation of mammalian ATG8s to phosphatidylethanolamine (PE) is a key step in autophag...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD025356 | Pride
Mitochondria Autophagy 
ProteomicsA novel enzyme-mediated method for covalent surface modification of extracellular vesicles to achieve targeted drug delivery
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. However, existing methods to engineer target-specific EVs are tedious or inefficient, having to compromise betwee...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD021926 | Pride
Extracellular vesicles Rbcevs Drug delivery 
Sort   by:  
 Page size