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ProteomicsMetabolite-protein covariation architecture identifies a cysteine shunt regulating liver cholesterol
Protein regulation of metabolic processes is foundational to biology. Here we develop a mass spectrometry-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues. This Metabolite Protein Covariation Architectu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD065355 | Pride
Lrrc58 Metabolism Cdo1 Do mice Cysteine Lasso Proteomics 
ProteomicsLactate regulates cell cycle and proliferation by remodeling the anaphase promoting complex
Lactate is abundant in rapidly dividing cells, due to the requirement for elevated glucose catabolism to support proliferation. However, it is not known whether accumulated lactate affects the proliferative state. Here, we deploy a systematic approach to determine lactate-dependent regulation of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD036641 | Pride
Tpp Lactate Cell cycle 
ProteomicsArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Obesity is a polygenic disorder with variable penetrance in the general population. Brown adipose tissue (BAT) is a major regulator of energy expenditure and metabolic physiology due to a specialized proteome that orchestrates futile metabolic cycles, which could be leveraged to treat obesity. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-08 | PXD036947 | Pride
Diversity outbred Qtl Physiology Metabolic disease Network Proteome Obesity Phenotype 
ProteomicsTHEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development
By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified ...
ORGANISM(S): Homo Sapiens 
2023-08-31 | PXD028689 |
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