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In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
Using CXMS to probe the effect of persulfidation on AtG6PD6 homooligomer structure. Abundant cross-links were identified within both AtG6PD6 monomer and oligomer (Datasets S2 and 3). Based on the cross-linking information, models of the AtG6PD6 dimer and tetramer structures were constructed.
ORGANISM(S): Arabidopsis Thaliana 
2023-07-20 | PXD043969 |
This study performed data-independent acquisition (DIA)-based quantitative proteomic analysis on paired cartilage samples from inflammatory and noninflammatory regions of knee osteoarthritis (OA) patients. The objective was to characterize the proteomic alterations associated with cartilage inflamma...
ORGANISM(S): Homo Sapiens 
we performed a comprehensive analysis of transcriptomics, proteomics and metabolomics on the potential mechanism of abrin injury in human lung epithelial cells.
ORGANISM(S): Homo Sapiens 
2019-01-18 | PXD012435 |
Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that card...
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072325 |
This dataset contains DIA-MS raw files and processed DIA-NN results from a DARTS-MS chemoproteomic experiment designed to identify ginkgolide J-associated protease-susceptibility candidate proteins in primary rat pulmonary artery smooth muscle cell (PASMC) lysates. The experiment included three grou...
ORGANISM(S): Rattus Norvegicus 
Bone loss in elderly males is associated with a high mortality rate because of fracture. A growing body of evidence indicates that low androgen levels are linked with bone loss in elderly men, suggesting that the regulatory role of androgen in aged male bones deserves more attention, and it is not e...
ORGANISM(S): Mus Musculus 
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