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ProteomicsSARS-CoV-2 ORF8 interactome in the secretory pathway
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032035 | Pride
Orf8 2-d gel Endoplasmic reticulum Lc-ms/ms 
UnknownUSP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Not available
S-EPMC10282087 | biostudies-literature
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownEngineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery.
Not available
S-EPMC6415439 | biostudies-literature
ProteomicsDIA-MS2pep : a library-free framework for comprehensive peptide identifications from DIA-data
We present, a new framework for library-free peptide identification from data-independent acquisition (DIA) data, DIA-MS2pep, containing two main components: 1) MS2 spectrum self-demultiplexing and 2) large precursor mass tolerance database search. DIA-MS2pep empowers the discovery capability of DIA...
ORGANISM(S): Homo Sapiens Escherichia Coli Caenorhabditis Elegans Saccharomyces Cerevisiae 
2022-03-14 | PXD032253 |
ProteomicsProteomic, phosphoproteomic and N-glycoproteomic analysis of small extracellular vesicles (sEVs) from C2C12 myoblasts
We conducted a comprehensive and integrated proteomic，phosphoproteomic, N-glycoproteomic analysis of the cargos in small extracellular vesicles (sEVs)-derived from C2C12 myoblasts.
ORGANISM(S): Mus Musculus 
2023-12-20 | PXD047974 |
ProteomicsIdentification of Small Open Reading Frame-encoded Peptides in Glioma by an Optimized Proteomics Strategy
Small open reading frame-encoded peptides (SEPs) are peptides or proteins encoded by previously unannotated sequences in the genome. Although ribosome profiling and bioinformatics could predict a large number of SEPs, mass spectrometry (MS) is the only direct method for their identification. However...
ORGANISM(S): Homo Sapiens 
PXD058073 |
ProteomicsProteomic of human plasma and serum-derived EVs
We isolated the high purity extracellular vesicles from human plasma and serum and performed DIA-MS.
ORGANISM(S): Homo Sapiens 
PXD041146 |
ProteomicsComprehensive evaluation of different TiO2-based phosphopeptide enrichment and fractionation methods for phosphoproteomics
We performed a comprehensive evaluation of four different TiO2-based phosphopeptide enrichment methods using different non-phosphopeptide excluders. Then, two phosphopeptide fractionation methods, including the ammonia-based and the TEA based high pH reversed-phase fractionation, are also evaluated.
ORGANISM(S): Homo Sapiens 
2022-06-02 | PXD034264 |
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD027958 |
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