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ProteomicsSARS-CoV-2 ORF8 interactome in the secretory pathway
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032035 | Pride
Orf8 2-d gel Endoplasmic reticulum Lc-ms/ms 
UnknownUSP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Not available
S-EPMC10282087 | biostudies-literature
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownEngineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery.
Not available
S-EPMC6415439 | biostudies-literature
ProteomicsDIA-MS2pep : a library-free framework for comprehensive peptide identifications from DIA-data
We present, a new framework for library-free peptide identification from data-independent acquisition (DIA) data, DIA-MS2pep, containing two main components: 1) MS2 spectrum self-demultiplexing and 2) large precursor mass tolerance database search. DIA-MS2pep empowers the discovery capability of DIA...
ORGANISM(S): Homo Sapiens Escherichia Coli Caenorhabditis Elegans Saccharomyces Cerevisiae 
2022-03-14 | PXD032253 |
ProteomicsProteomic, phosphoproteomic and N-glycoproteomic analysis of small extracellular vesicles (sEVs) from C2C12 myoblasts
We conducted a comprehensive and integrated proteomic，phosphoproteomic, N-glycoproteomic analysis of the cargos in small extracellular vesicles (sEVs)-derived from C2C12 myoblasts.
ORGANISM(S): Mus Musculus 
2023-12-20 | PXD047974 |
ProteomicsIdentification of Small Open Reading Frame-encoded Peptides in Glioma by an Optimized Proteomics Strategy
Small open reading frame-encoded peptides (SEPs) are peptides or proteins encoded by previously unannotated sequences in the genome. Although ribosome profiling and bioinformatics could predict a large number of SEPs, mass spectrometry (MS) is the only direct method for their identification. However...
ORGANISM(S): Homo Sapiens 
2025-05-05 | PXD058073 |
ProteomicsProteomic of human plasma and serum-derived EVs
We isolated the high purity extracellular vesicles from human plasma and serum and performed DIA-MS.
ORGANISM(S): Homo Sapiens 
2023-03-28 | PXD041146 |
ProteomicsComprehensive evaluation of different TiO2-based phosphopeptide enrichment and fractionation methods for phosphoproteomics
We performed a comprehensive evaluation of four different TiO2-based phosphopeptide enrichment methods using different non-phosphopeptide excluders. Then, two phosphopeptide fractionation methods, including the ammonia-based and the TEA based high pH reversed-phase fractionation, are also evaluated.
ORGANISM(S): Homo Sapiens 
2022-06-02 | PXD034264 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
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