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ProteomicsRewiring the metabolic network to increase docosahexaenoic acid productivity in Crypthecodinium cohnii by fermentation supernatant-based adaptive laboratory evolution
To overcome the inhibition caused by the fermentation supernatant in the late fermentation stage of docosahexaenoic acid (DHA)-producing Crypthecodinium cohnii, fermentation supernatant-based adaptive laboratory evolution (FS-ALE) was conducted. The cell growth and DHA productivity of the evolved st...
ORGANISM(S): Crypthecodinium Cohnii 
2021-11-27 | PXD030028 |
ProteomicsProteomics analysis identifies IRSp53 and Fascin as critical for PRV egress and direct cell-cell transmission
Pseudorabies virus (PRV) has been widely used as a live transsynaptic tracer for mapping neuronal circuits. Systematically identifying mature PRV virion proteomes and defining copurified host proteins are necessary to fully understand the detailed mechanism underlying PRV transmission p...
ORGANISM(S): Mus Musculus 
2019-09-18 | PXD015490 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsCharacterization, Antioxidant Effects of Lycium ruthenicum Murr. Polysaccharides and its Protective Effects Against Oxaliplatin-Induced Peripheral Neurotoxicity by Inhibiting the RAS-RAF-MEK-ERK Signaling Pathway
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
ProteomicsQuantitative proteomics investigation of total protein and acetylated 4D Label free of 18 samples from H9C2 cells
The quantitative investigation of acetylated proteomics was carried out in this project. To ensure high reliability of the results, we filtered the identification data using a criterion of localization probability>0.75. This study identified a total of 9755 acetylation sites located on 3051 proteins...
ORGANISM(S): Rattus Norvegicus 
2023-06-16 | PXD043035 |
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