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TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
UnknownCurrent guidelines on the management of gestational diabetes mellitus: a content analysis and appraisal.
Not available
S-EPMC6567433 | biostudies-literature
UnknownA systematic review for the impacts of global approaches to regulating electronic nicotine products.
Not available
S-EPMC10451104 | biostudies-literature
TranscriptomicsAnalysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
Alginate overproduction by P. aeruginosa, also known as mucoidy is associated with chronic endobronchial infections in cystic fibrosis (CF). Alginate biosynthesis in this bacterium is initiated by the extracytoplasmic function sigma factor (σ22, AlgU/T). In the wild type (wt) nonmucoid strains, su...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-01 | E-GEOD-35248 | biostudies-arrayexpress
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-05 | PXD013414 | Pride
Metabolism Atr Mitochondrial function 
ProteomicsTrrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity
The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-02 | PXD013730 | Pride
Trrap Neurodegeneration Lysine acetylation Sp transcription factors Wnt signalling 
ProteomicsCooperative treatment effectiveness of VE821 and AUY922 in Ewing’s sarcoma cells
Ewing's sarcoma (ES) is the second most frequent bone cancer during childhood and adolescence originating from a translocation between the EWSR1 and the FLI1 gene, which inactivates BRCA-mediated DNA damage response. Both ATR and HSP90 inhibitors are promising new candidates in the field of ES treat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021562 | Pride
Ewing's sarcoma 
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD013469 | Pride
Metabolism Atr Mitochondrial function 
UnknownEpigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group.
Not available
S-EPMC3438233 | biostudies-literature
UnknownIssues in patients' experiences of enhanced recovery after surgery (ERAS) : a systematic review of qualitative evidence.
Not available
S-EPMC9945048 | biostudies-literature
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