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TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
TranscriptomicsTRRAP-mediated regulation of Wee1
The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Up-regulation of Chk1 by mutation or overexpression bypasses the requirement for up-stream regulators or DNA damage to promote a G2 cell cycle arrest. We screened i...
ORGANISM(S): Schizosaccharomyces pombe 
2010-04-11 | E-GEOD-12674 | biostudies-arrayexpress
TranscriptomicsCell cycle dependence of neuroprogenitor fate determination regulated by Trrap-mediated histone acetylation
Epigenetic control of neural stem/progenitor cell fate is fundamental to achieve a fully brain architecture. Two intrinsic programs regulate neurogenesis, one by epigenetic-mediated gene transcription and another by cell cycle control. Whether and how these two are coordinated to determine temporall...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-43650 | biostudies-arrayexpress
ProteomicsTrrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity
The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-02 | PXD013730 | Pride
Trrap Neurodegeneration Lysine acetylation Sp transcription factors Wnt signalling 
GenomicsHAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
PRJNA542345 | ENA
GenomicsThe TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
PRJNA719720 | ENA
ProteomicsA CHD8-TRRAP axis facilitates MYC- and E2F-target gene regulation in human neural stem cells.
Mutations in ATP-dependent chromatin remodeler CHD8 cause one of the most frequent monogenetic forms of autism and also associate with brain overgrowth. Nevertheless, activities of CHD8 in autism-relevant cell types are still poorly understood. Here we purify the CHD8 protein from human neural stem ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044582 | Pride
Neural stem cells Chd8 Myc Gene regulation Ez2f 
GenomicsRNA-seq of different brain tissue areas of Trrap conditional knockout Mus musculus
RNA-seq of different brain tissue areas of Trrap conditional knockout Mus musculus
PRJNA543117 | ENA
GenomicsThe TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells II
The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells II
PRJNA791840 | ENA
GenomicsTRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition
TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition
PRJNA1419729 | ENA
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