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GenomicsGenome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia
The AML1/ETO fusion protein is essential to the development of acute myeloid leukemia (AML), and is well recognized for its dominant-negative effect on the co-existing wild-type protein AML1. However, the involvement of wild-type AML1 in AML1/ETO-driven leukemogenesis remains elusive. Through chroma...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-65427 | biostudies-arrayexpress
ProteomicsSCF dynamics regulated by CAND2
The effect of CAND2 on SCF dynamics was studied by AP-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-01-20 | PXD045618 | Pride
Scf  dynamics  cand2 
ProteomicsDissociation profile of F-box proteins
Dissociation rate of different F-box proteins from CUL1 was studied by AP-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-01-20 | PXD045616 | Pride
Dissociation  f-box protein 
Proteomicsproteome turnover assay in WT and CAND2 KO JMSU1 cells
This assay was used to assess the effect of CAND2 on global protein turnover in JMSU1 cells.
ORGANISM(S): Homo sapiens (Human) 
2025-01-20 | PXD056464 | Pride
Cand2  protein turnover 
ProteomicsSFOme in WT and CAND2 KO HEK293 cells
This assay was used to assess the SCF assembly levels in WT and CAND2 HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2025-01-20 | PXD056462 | Pride
Scf cand2 
ProteomicsSILAC proteomics studying the role of CAND1 in CRL2 dynamics
Effects of CAND1 and neddylation/deneddylation on CRL2 dynamics.
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD045609 | Pride
Cul2 exchange 
ProteomicsDynamic exchange of CRL4 regulated by CAND1 and CAND2
CAND1 and CAND2 have been established as exhange factors for CRL1s, however, how they regulate the dynamic exchange of CRL4s remains not fully understood. This project aims to study and compare the effect of CAND proteins on the exchange levels of multiple DCAFs, thus providing insights into the fun...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD063817 | Pride
Silac  human  cullin-ring ubiquitin ligases 
TranscriptomicsThe Time-Series Transcriptomic Responses of THP-1 Cells to W-Beijing M. tuberculosis Strains of different sublineages
We report a whole-genome expression profiling of PMA-treated THP-1 human macrophages as a host system, infected by W-Beijing strains of different sublineages or the H37Rv reference strain. Surprisingly, we found that host transcriptional responses were irrespective of inter-sublineage variations. Ba...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-29628 | biostudies-arrayexpress
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