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TranscriptomicsExpression data from MDA-MB-231 cells treated with vehicle or YW3-56
PAD4 is overexpressed in many cancer cells. We developed PAD inhibitors that efficiently inhibit the cancer cell growth. One inhibitor YW3-56 could efficiently induce cell death of triple negative breast cancer MDA-MB-231 cells. We used microarray to detail the global gene expression of MDA-MB-231 b...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-46590 | biostudies-arrayexpress
ProteomicsThe melanoma cell line MDA-MB-435 adhesome in long-term culture and its comparison to the adhesome upon integrin αV knockdown
Using mass spectrometry–based proteomics, we analysed the components of integrin adhesion complexes of MDA-MB-435S cells and two MDA-MB-435S-derived integrin αV-specific shRNA-expressing cell clones. Among integrins, we detected αV and β5 integrin subunits in the MDA-MB-435S adhesome, thus showing t...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD016837 | Pride
Human Cancer Mda-mb-435s Integrin adhesion complex Adhesome Integrin αvβ5 Melanoma Cortical microtubule stabilisation complex 
TranscriptomicsDeep sequencing of exosomal and cellular miRNAs in MDA-MB-231 and MCF-10A cells
To identify the miRNAs that are differentially expressed and secreted between the MDA-MB-231 metastatic breast cancer cells and the MCF-10A non-cancerous human mammary epithelial cells, we profiled the cellular and exosomal small RNAs (between 17 and 52 nt) isolated from these two cell lines by Sole...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-50429 | biostudies-arrayexpress
TranscriptomicsAcquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”
Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.
ORGANISM(S): Homo sapiens 
2014-09-01 | E-MEXP-3982 | biostudies-arrayexpress
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
GenomicsIdentification of p63 binding regions in a p63 expressing basal-subtype breast cancer cell line, MCFDCIS.
p63 ChIP-SEQ in a p63 expressing basal-subtype breast cancer cell line, MCFDCIS and in a p63 deficient claudin-low subtype breast cancer cell line, MDA-MB-231 p63 ChIP-SEQ on MCFDCIS and MDA-MB-231 cell lines
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-72009 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip from MDA-MB-231 cells with PHF1, CUL4B and PRMT5
It has been reported that PHF1, CUL4B and PRMT5 all play important roles in epigenetic regulation. We reported that PHF1, CRL4B and PRMT5 may act as a complex in transcriptional regulation and have a vital effect in breast cancer progression. So we performed ChIP-on-chip assays to find unique promot...
ORGANISM(S): Homo sapiens 
2016-07-07 | E-GEOD-84071 | biostudies-arrayexpress
ProteomicsHuman Angiotensin-Converting Enzyme 2-Specific Benzothiazole Allosteric Inhibitor against Pan-Sarbecoviruses
Emerging SARS-CoV-2 variants of concern (VOCs) have demonstrated exceptional transmissibility and a strong dependence on the cellular receptor human angiotensin-converting enzyme 2 (hACE2). In this study, we present MB-32, a benzothiazole-based small molecule allosteric inhibitor of hACE2, w...
ORGANISM(S): Homo sapiens (Human) Sarbecovirus 
2026-05-01 | PXD075140 | Pride
Human Mb-32 Entry inhibtor Angiotensin-converting enzyme 2 Covid19 Allosteric inhibitor Sarbecovirus Benzothiazole Formaldehyde crosslinking 
GenomicsPCGP MB WGS Full - samples
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
EGAD00001001864 | EGA
TranscriptomicsGene expression in human breast cancer cell lines regulated by HIC1 gene
This study aimed to further our understanding of the role that hypermethylatioted in cancer 1 (HIC1) plays in breast cancer progression. Microarrays were searched for some genes that had correlated expression with HIC1 mRNA. According to fold-change screening between restoring expression of HIC1 and...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-50061 | biostudies-arrayexpress
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