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TranscriptomicsNormal Lung + Lung adenocarcinoma microarray
Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be eit...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-231 | biostudies-arrayexpress
GenomicsASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
ChIP-Seq analysis performed on 5 ASCL1(+) cell lines and 2 ASCL1 (-) cell lines in order to understand the transcriptome of ASCL1 as it pertains to high-grade neuroendocrine lung cancers 5 ASCL1(+) lung cancer cell lines and 2 ASCL1(-) lung cancer cell lines were compared using ChIP-Seq analysis
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61197 | biostudies-arrayexpress
TranscriptomicsExpression profiling of lung cancer cell lines (UTSW Lung Panel V2)
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-32989 | biostudies-arrayexpress
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029972 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer (batch2-6)
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029968 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD013298 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-22 | PXD013267 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
UnknownConserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays.
Not available
S-EPMC546166 | biostudies-literature
UnknownRapid Neuromodulation of Layer 1 Interneurons in Human Neocortex.
Not available
S-EPMC5946807 | biostudies-literature
UnknownProbe mapping across multiple microarray platforms.
Not available
S-EPMC3431719 | biostudies-literature
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