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ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
ProteomicsQuantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-Cov-2 innate immune evasion
We used two model systems to characterise the changes caused by SARS-CoV-2 using quantitative proteomics. We used primary human epithelial cells differentiated at the air-liquid interface, first describing the relative abundance of proteins found in each major cell type of the epithelium, and then c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD034135 | Pride
Sars-cov-2 Hbec 
GenomicsComparative DNA methylome analysis of endometrioid adenocarcinoma, uterine papillary serous carcinoma, and normal endometrium
Classically, there are two types of endometrial cancer, endometrioid adenocarcinoma (EAC), or Type I; and uterine papillary serous carcinoma (UPSC), or Type II. These two types of cancers exhibit distinct DNA methylation levels in promoters of many genes. In EAC, many tumor suppressor genes were sil...
ORGANISM(S): Homo sapiens 
2014-10-12 | E-GEOD-51565 | biostudies-arrayexpress
TranscriptomicsKras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma
This SuperSeries is composed of the following subset Series: GSE27478: Gene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice GSE33322: Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-c...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33323 | biostudies-arrayexpress
ProteomicsDefining neutralization and allostery by antibodies against COVID-19 variants
This project is aimed at characterizing the interactions of SARS-CoV-2 Spike protein and its variants with multiple full-length antibodies and monitoring the accompanying conformational dynamics. Different categories of antibodies are tested that recognize different domains of the Spike protein. The...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043818 | Pride
Antibody Epitope-paratope mapping Sars-cov-2 Hdxms Neutralization Md simulations Variants of concern Spike protein 
UnknownCytogenetic prognostication within medulloblastoma subgroups.
Not available
S-EPMC3948094 | biostudies-literature
UnknownA bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum.
Not available
S-EPMC3811051 | biostudies-literature
TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
UnknownLoss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.
Not available
S-EPMC5816015 | biostudies-literature
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