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ProteomicsExosome-Based Proteomic Profiling for Biomarker Discovery in Pediatric Fabry Disease: Insights into Early Diagnosis Monitoring
Background: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by GLA mutations, leading to deficient α-galactosidase A (α-Gal A) activity and progressive glycosphingolipid accumulation. While α-Gal A activity is the diagnostic gold standard, its sensitivity is reduced in late-onset...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD069403 | Pride
Child Fabry disease Exosome Biomarkers 
ProteomicsMosaic PKHD1 variants in polycystic kidney caused aberrant protein profiling of mitochondria and lysosomes
Autosomal recessive polycystic kidney disease (ARPKD) is a severe renal cystic disease mainly caused by PKHD1. However, its genetic cause, pathological features, and mechanism remained unsolved. Our findings may provide new insight on the pathophysiology of the polycystic kidney due to PKHD1 deficie...
ORGANISM(S): Homo Sapiens 
2021-08-20 | PXD028042 |
ProteomicsProteomic landscape of serum exosomes to identify potential therapeutic targets.
Using a tandem mass tag (TMT)-based quantitative proteomics approach, we characterized the proteomes of individual patient-derived serum exosomes, identified exosomal protein signatures specific to TNBC patients, and filtered out differentially expressed proteins.
ORGANISM(S): Homo Sapiens 
2021-08-04 | PXD027696 |
ProteomicsIdentified potential interacting proteins of WRN
We used anti-WRN antibody to perform immunoprecipitation assay through oncosphere lysates and identified a potential interacting protein candidate
ORGANISM(S): Homo Sapiens 
2023-08-25 | PXD044847 |
ProteomicsMolecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules
The production of secondary metabolites is one of the major mechanisms for beneficial rhizobacteria to antagonize plant pathogens. However, simultaneously producing large quantities of different secondary metabolites can pose great metabolic burdens and exerts a significant fitness cost on the produ...
ORGANISM(S): Pseudomonas Fluorescens F113 
2021-04-15 | PXD025403 |
ProteomicsComprehensive mass spectral libraries of human thyroid tissue and cells
We established deep-coverage thyroid-specific spectral libraries encompassing over 12,000 proteins, including samples from nine types of thyroid primary and lymph node metastases tissues and fifty thyroid cancer cell lines.
ORGANISM(S): Homo Sapiens 
2024-09-27 | PXD051051 |
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