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TranscriptomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [RNA-Seq]
Purpose: The aim of this study is to identify genes that are under the transcriptional control of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain Methods: Total RNA was extracted using an AllPrep DNA/RNA Mini Kit (Qiagen) from cultured neural stem cells der...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65747 | biostudies-arrayexpress
GenomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [ChIP-Seq, MBD-Seq]
Purpose: The aim of this study is (1) to identify the chromatin occupancy of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain; (2) to profile key epigenetic marks H3K4me3, H3K27me3 and DNA methylation in wild type and Smchd1 null NSCs; (3) to identify the ch...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65748 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-65749 | biostudies-arrayexpress
ProteomicsMouse embryonic stem cells LCMS-MS
We hypothesized that uncovering interactions between Pfkp and other proteins could help resolve the mechanism whereby Pfkp regulates germ layer differentiation. Towards this, Pfkp was immunoprecipitated from mESCs and mass spectrometry analysis used to identify a number of potential Pfkp-interacting...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-23 | PXD038944 | Pride
Lcms-ms Mouse Embryonic stem cells 
ProteomicsDifferential proteomic and phosphoproteomic analysis of Hnrnpk conditional knockout mouse testes
In this research, we have used a global analysis of TMT-based quantitative proteome coupled with phosphopeptide-enrichment strategies to reveal the mouse testes proteome and find the PTMs associated with the RNA binding protein hnRNPK using Hnrnpk conditional knockout mouse and WT mouse testes.
ORGANISM(S): Mus Musculus 
2024-09-14 | PXD056125 |
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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