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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownA Bayesian network meta-analysis of the primary definitive therapies for locoregionally advanced nasopharyngeal carcinoma: IC+CCRT, CCRT+AC, and CCRT alone.

Background

The major aim of this Bayesian network analysis was to determine the optimal treatment strategy for locoregionally advanced nasopharyngeal carcinoma (LANPC).

Method

We systematically searched databases and extracted data from randomized clinical trials involving LANPC patie...
S-EPMC8932567 | biostudies-literature
ProteomicsMoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae
A convergent screening strategy was employed to systematically identify mitophagy regulators within the IMM. The quantitative proteomic comparison between the WT and ΔMoatg1 mutant under nutrient-replete (CM) and nitrogen-starvation (CM-N) conditions was conducted using TMT-labeled quantitative prot...
ORGANISM(S): Pyricularia oryzae 70-15 
2026-09-14 | PXD075441 | Pride
Mitophagy Succinylation Cox6 Fungicide Magnaporthe oryzae 
UnknownCD38 promotes angiotensin II-induced cardiac hypertrophy.
Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signalling pathways. Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H2 O2 -indu...
S-EPMC5542907 | biostudies-literature
UnknownCD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.
Ischemia/reperfusion (I/R) injury induces irreversible oxidative stress damage to the cardiac muscle. We previously observed that CD38 deficiency remarkably protects mouse embryonic fibroblasts (MEFs) from oxidative stress-induced injury. However, whether CD38 deficiency protects from I/R injury in ...
S-EPMC4983367 | biostudies-literature
UnknownProteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo.
Not available
S-EPMC5830835 | biostudies-literature
UnknownHigh Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome.

Objective

Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well...
S-EPMC7943292 | biostudies-literature
Unknown5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients.

Background

Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are responsive to the scheme, and there is no effective method to predict treatmen...
S-EPMC7879534 | biostudies-literature
ProteomicsElectroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
Electroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
ORGANISM(S): Rattus Norvegicus 
2022-11-29 | PXD038461 |
UnknownClopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.

Importance

Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking.

Obj...

S-EPMC10928538 | biostudies-literature
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