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TranscriptomicsRNA-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 24 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). HOX transcription factors have been historically implicated in axial elongation, with their sequential activation playing a fu...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9773 | biostudies-arrayexpress
TranscriptomicsATAC-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). WNT signalling sustains both NMP expansion and PM differentiation, but the mechanism by which it distinguishes between these a...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9776 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of tailbuds from control, Pbx1/Pbx2 compound and Pbx1/Pbx2 double-knockout E8.5/E9.0 embryos.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). NMPs reside in the caudal lateral epiblast and tailbud, from where they sustain axial elongation. HOX transcription factors ha...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9785 | biostudies-arrayexpress
TranscriptomicsChIP-seq of PBX1, PBX2 and LEF1 in wild-type and Pbx1/Pbx2 double-knockout EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). WNT signalling sustains both NMP expansion and PM differentiation, but the mechanism by which it distinguishes between these a...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9775 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of wild-type and Pbx1/Pbx2 double-knockout EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). HOX transcription factors have been historically implicated in axial elongation, with their sequential activation playing a fu...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9774 | biostudies-arrayexpress
UnknownA novel virus potentially evolved from the N4-like viruses represents a unique viral family: <i>Poorviridae</i>.
Not available
S-EPMC11654794 | biostudies-literature
ProteomicsProteomic analysis of extracellular membrane vesicles produced from Staphylococcus aureus biofilm and planktonic cultures
This project investigates the role of extracellular membrane vesicles (MVs) in Staphylococcus aureus biofilm formation. To elucidate how MVs contribute to this process, we conducted a proteomic analysis to identify and compare proteins present in the S. aureus MN8 biofilm matrix, as well as proteins...
ORGANISM(S): Staphylococcus aureus subsp. aureus MN8 
2026-08-03 | PXD075156 | Pride
Extracellular vesicles Mn8 Biofilm Staphylococcus aureus Biofilm matrix 
ProteomicsProtein compositions of extracellular vesicles released from Staphylococcus aurues JE2 and its lgt mutant
This project detected the protein composition of extracellular vesicles (EV) produced by S. aureus WT JE2 strain and its lgt mutant (lipoprotein deficient mutant). Our recent study found that mutation of lgt in S. aureus USA300 JE2 strain significantly increased EV production in S. aureus and decrea...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD014888 | Pride
Staphylococcus aureus Vesicle Lgt 
ProteomicsLC-MS of extracellular vesicles from Staphylococcus aureus USA300 JE2 and its agrspa double mutant strain
This project aims to identify the extracellular vesicles (EVs) from Staphylococcus aureus USA300 JE2 strain. In addition, we also detoxified the EVs by mutation of agr ad spa genes in JE2 and evaluated the immunogenicity and protection of the detoxified EVs. These proteins from these detoxified EVs...
ORGANISM(S): Staphylococcus aureus 
2018-10-23 | PXD007953 | Pride
Extracellular vesicle Usa300 Mutant Staphylococcus aureus 
UnknownQing-Kai-Ling oral liquid alleviates non-alcoholic fatty liver disease via remodeling gut microbiota and activating AMPK/ACC1 axis.
Not available
S-EPMC12536533 | biostudies-literature
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