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MetabolomicsWhole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights
UnknownEvaluation of the antibacterial activity of Elsholtzia ciliate essential oil against halitosis-related Fusobacterium nucleatum and Porphyromonas gingivalis
Not available
S-EPMC10440386 | biostudies-literature
MetabolomicsComprehensive Untargeted Metabolomics Dataset of Saccharomyces cerevisiae Aging-Associated Mutants and Yeast–Host Interactions in Drosophila melanogaster

Aging is a complex biological process influenced by genetic factors, environmental conditions, and interactions between organisms and their associated microbes. The budding yeast Saccharomyces cerevisiae and the fruit fly Drosophila melanogaster provide complementary model systems for investigati...

2026-09-04 | MTBLS15555 | MetaboLights
Genomicsspike-in
spike-in
2026-09-09 | OEX00033626 | NODE
ProteomicsProteomic Profiling of Donkey Milk Exosomes Highlights Bioactive Proteins with Immune-Related Functions
Proteomic profiles of exosomes isolated from donkey colostrum and mature milk using advanced four-dimensional (4D) label-free quantitative proteomics. A comprehensive analysis identified and quantified a total of 2,293 exosomal proteins from donkey milk, including 276 differentially expressed exosom...
ORGANISM(S): Equus Asinus X Caballus 
2025-03-18 | PXD061958 |
ProteomicsDe Novo Sequencing of N-Glycosylated Light Chains in AL Amyloidosis
We established an integrative de novo sequencing workflow to resolve the complete amino acid sequence of N-glycosylated LCs isolated from the urine of AL patients.
ORGANISM(S): Homo Sapiens 
2026-04-16 | PXD077287 |
ProteomicsInteractome analysis for Kdm4B
In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed ...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2023-08-12 | PXD039097 | JPOST Repository
ProteomicsPhosphoproteomic analysis reveals the effects of sleep deprivation on the hippocampus of mice
Sleep deprivation has a significant effect on the level of protein phosphorylation modification in the hippocampus of mice.
ORGANISM(S): Mus Musculus 
2022-06-29 | PXD034972 |
ProteomicsLabel-free quantitative proteomic analysis of rat liver tissue
In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free p...
ORGANISM(S): Rattus Rattus 
2019-09-14 | PXD015449 |
ProteomicsProteome of parthenogenetic and bisexual ovarian tissues of Haemaphysalis longicornis at different feeding stages
The vector tick Haemaphysalis longicornis exhibits two reproductive strategies: bisexual populations (HLBP) and parthenogenetic populations (HLPP). To understand the molecular function of genes associated with H. longicornis ovarian development, an integration of quantitative proteomics was carried...
ORGANISM(S): Haemaphysalis Longicornis 
2021-11-01 | PXD029485 |
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