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Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
Aquaporins (AQPs) are essential membrane proteins that facilitate the transmembrane transport of water and solutes, and play a key role in osmoregulation in many animals, but their response mechanism to low temperature stress in ticks remains unclear.
ORGANISM(S): Haemaphysalis Longicornis 
2024-11-19 | PXD058058 |
Widespread intraperitoneal metastases and chemoresistance has made ovarian cancer the leading cause of gynecological malignancy–related deaths, wherein TGF-β signaling plays the pivotal role by promoting cancer stem cells (CSCs) activity. Whereas, how the signaling is activated and how to target TGF...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050476 |
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