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MetabolomicsA metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanisms by which CR improves health, particularly brain health, ar...
2025-07-31 | MTBLS8006 | MetaboLights
TranscriptomicsIdentifying genes dysregulated in patients with acute myocardial infarction
Twenty-three AMI patients and 23 non-AMI healthy controls were included in this pilot study. Tissue samples were cut at 10 μm from formalin fixed paraffin-embedded tissue blocks using a microtome. Six to eight 10-μm sections were used for the isolation procedure. Total RNA isolation was performed us...
ORGANISM(S): Homo sapiens 
2016-05-11 | E-MTAB-3573 | biostudies-arrayexpress
Proteomicsthe Effect of Fatty Acids in Hepatic Insulin resistance-part2
Monounsaturated fatty acid (MUFA) oleic acid (OA) has been reported to reverse saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). However, the detailed molecular mechanism remains elusive. In addition, previous research also showed that -3 polyunsaturated fatty acid (PU...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012066 | Pride
Human  free fatty acids  insulin resistance  quantitative proteomics  calcium  atp. 
ProteomicsGrass carp SERPINA1 CoIP with hepatopancreas mass spectrometry analysis
SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases. To further investigate the antiviral role SERPINA1 played in GCRV (Grass carp Reovirus) infection, a polyclonal antibody of SERP...
ORGANISM(S): Ctenopharyngodon idella 
2022-08-31 | PXD036356 | Pride
Serpina1 Grass carp Coip/ms Hepatopancreas 
ProteomicsProteomic of grass carp (Ctenopharyngodon Idella) five tissues before and after GCRV infection
Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) fr...
ORGANISM(S): Ctenopharyngodon Idella 
2024-10-20 | PXD056989 |
ProteomicsLabel-free proteomics of endometrial epithelial cell for identification of presumptive biomarkers of endometritis
A total of 1180 proteins were identified in the control group and endometritis model group, of which 313 differential proteins were accurately quantified. The proteomic results were verified by WB, TEC and IF techniques, and the same conclusion was obtained.
ORGANISM(S): Capra Hircus 
2022-05-18 | PXD033950 |
ProteomicsProteomic study on lavage fluid of Dairy cows 30 days after delivery
Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria that is involved in pathogenic processes leading to postpartum metritis and endometritis in dairy cow. It also causes inflammation of the endometrium. This study aimed to investigate the effects of LPS on cow end...
ORGANISM(S): Bos Taurus 
2022-08-23 | PXD036248 |
ProteomicsThe Effect of Fatty Acids in Hepatic Insulin Resistance - Part 1
Monounsaturated fatty acid (MUFA) oleic acid (OA) has been reported to restore saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). However, the detailed molecular mechanism remains elusive. In addition, -3 polyunsaturated fatty acid (PUFA) such as Eicosapentaenoic acid (...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012065 | Pride
Fatty acids  insulin resistance  pa  epa 
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
ProteomicsCLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.
ORGANISM(S): Mus Musculus 
2022-03-31 | PXD032057 |
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