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Background: Asthma involves chronic inflammation linked to metabolic reprogramming, but how metabolites reshape epigenetics through post-translational modifications remains unclear. Methods: We used HDM-induced asthmatic mice with multi-omics analyses (metabolomics, PTM-proteomics, ChIP-seq) and val...
ORGANISM(S): Homo Sapiens 
2025-11-12 | PXD070618 |
This study aimed to identify the interacting proteins of Polyglutamine-Binding Protein 1 (PQBP1) in human bronchial epithelial cells (BEAS-2B). We performed immunoprecipitation coupled with mass spectrometry (IP-MS) using Flag-tagged PQBP1 as bait, with an empty vector transfection as a control. Thi...
ORGANISM(S): Homo Sapiens 智人 
2025-11-13 | PXD070678 |
This study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. Specifically, the study focused on macrophage polarization and metabolic changes that may ...
ORGANISM(S): Mus Sp. 
2025-01-10 | PXD059614 |
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