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ProteomicsThe deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis
Spermiogenesis defines the final phase of male germ cell differentiation. Multiple deubiquitinating enzymes have been linked to spermiogenesis, yet the impacts of deubiquitination on spermiogenesis remain poorly characterized. Here, we investigated the function of UAF1 in mouse spermiogenesis and ma...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-07 | PXD046120 | Pride
Uaf1 usp1 male infertility spermiogenesis deubiquitylation 
UnknownTranscriptomics and metabolomics revealed the molecular basis of the color formation in the roots of <i>Panax notoginseng</i>.
Not available
S-EPMC11459398 | biostudies-literature
ProteomicsAvian pathogenic Escherichia coli infection causes infiltration of heterophilic granulocytes of chick tracheal by the complement and coagulation cascades pathway
Tracheal mucosal epithelial cells were scraped at 12 and 24 hours of infection, frozen in liquid nitrogen and stored at -80°C. The cells were sent to a biotechnology company for TMT quantitative proteomic analysis. The cells were sent to a biotech company for TMT quantitative proteomics analysis.
ORGANISM(S): Gallus gallus (Chicken) 
2024-01-26 | PXD044411 | Pride
Avian pathogenic escherichia coli  ae17  tmt-sequencing  complement and coagulation cascades pathways  pathogenicity 
MetabolomicsBlood pseudotargeted metabolome of moyamoya disease

We aimed to identify specific metabolomic changes and biomarkers for the differential clinical diagnosis of different subtypes of moyamoya disease (MMD). We conducted an pseudotargeted metabolomics analysis and pseudotargeted metabolomics analysis revealed decreased LPC expression in patients wit...

2024-10-31 | MTBLS10304 | MetaboLights
ProteomicsYKT6 is essential for male fertility by promoting meiosis progression through vesicular transport regulation during spermatogenesis of mice
The tetraploid spermatocytes of postnatal days (PD) 16 Ykt6-Ctrl and Ykt6-cKO mice obtained by fluorescence-activated cell sorting were subjected to proteomics analysis. After three rinses with phosphate-buffered saline (PBS), the samples were gathered into tubes containing lysis buffer, flash froze...
ORGANISM(S): Mus Musculus 
PXD063213 |
ProteomicsChronotoxici-plate Containing Rhythmic Liver Organoids for Drug Screening
The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many best-selling and WHO essential drugs, traditional approaches can’t satisfy the need of explore multi-...
ORGANISM(S): Mus Musculus 
PXD043268 |
ProteomicsClinical proteomics analysis using Data Independent Acquisition-Mass Spectrometry (DIA-MS) identified classifiers for molecular characterization of Lymphoma
In this study, we conducted a proteomics analysis on 109 fresh-frozen lymph node samples from clinical patients, covering a comprehensive suite of lymphoma subtypes including B-NHL, T-NHL, HL, Lymphadenitis, Tumor metastatic lymph node (TLN), and Non-neoplastic lymph node (TNM: N0).
ORGANISM(S): Homo Sapiens 
2020-01-15 | PXD017096 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
PXD020653 |
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