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ProteomicsUSP1 expression driven by EWS-FLI1 transcription factor stabilizes Survivin and promotes Ewing sarcoma cell survival
Ewing sarcoma (EWS) is a malignant pediatric bone cancer. Most Ewing sarcomas are driven by EWS-FLI1 oncogenic transcription factor that plays roles in transcriptional regulation, DNA damage response, cell cycle checkpoint control, and alternative splicing. USP1, a deubiquitylase which regulates DNA...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041033 | Pride
Ews-fli1 Usp1 Survivin 
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77423 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77419 | biostudies-arrayexpress
ProteomicsThe deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis
Spermiogenesis defines the final phase of male germ cell differentiation. Multiple deubiquitinating enzymes have been linked to spermiogenesis, yet the impacts of deubiquitination on spermiogenesis remain poorly characterized. Here, we investigated the function of UAF1 in mouse spermiogenesis and ma...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-07 | PXD046120 | Pride
Uaf1 usp1 male infertility spermiogenesis deubiquitylation 
GenomicsUbiquitinated PCNA drives USP1 synthetic lethality in cancer
Ubiquitinated PCNA drives USP1 synthetic lethality in cancer
PRJNA883979 | ENA
GenomicsGene expression changes in breast cancer cells upon USP1 knockdown [RNA-Seq]
Gene expression changes in breast cancer cells upon USP1 knockdown [RNA-Seq]
PRJNA438337 | ENA
GenomicsThe deubiquitinase USP1 promotes the progression of AML by stabilizing ID1 [RNAseq_AML_shUSP1]
The deubiquitinase USP1 promotes the progression of AML by stabilizing ID1 [RNAseq_AML_shUSP1]
PRJNA1374079 | ENA
GenomicsUSP1 modulates hepatocellular carcinoma progression via Hippo/TAZ axis
USP1 modulates hepatocellular carcinoma progression via Hippo/TAZ axis
PRJNA903373 | ENA
OtherUbiquitinated PCNA drives USP1 synthetic lethality in cancer
CRISPR Cas9-based functional genomics screening is a powerful approach for identifying and characterizing novel oncology drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitinating enzyme USP1 in cancers with underlying DNA damage vulnerabilities, specifically BRCA1/2 mutant ...
ORGANISM(S): Homo sapiens 
2022-09-27 | GSE214121 | GEO
GenomicsUSP1 identified as an important factor in the progression of gastric cancer
USP1 identified as an important factor in the progression of gastric cancer
PRJNA1190402 | ENA
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