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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human trauma patients with and without haemorrhagic shock
Patients were recruited between February 2008 and March 2019 through the Activation of Coagulation and Inflammation in Trauma (ACIT-II) study, a prospective platform cohort study evaluating aspects of coagulation and inflammation in trauma patients (NHS REC: 07/Q0603/20). Patients at the Royal Londo...
ORGANISM(S): Homo sapiens 
2026-10-29 | E-MTAB-16212 | biostudies-arrayexpress
TranscriptomicsProtein profiling reveals five principal chromatin types in Drosophila cells
The local protein composition of chromatin is important for the regulation of transcription and other functions. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin typ...
ORGANISM(S): Drosophila melanogaster 
2010-10-01 | E-GEOD-22069 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in a variety of normal, premalignant and squamous cell carcinomas of the cervix
We sought to apply the technologies of gene expression profiling to detect genes significant in the aetiology of cervical carcinoma . We investigated 14 normal (NAD), 11 low grade squamous intrapepithelial lesions (LSIL), 21 high grade squamous intraepithelial lesions (HSIL) and 28 squamous cell ca...
ORGANISM(S): Homo sapiens 
2013-09-17 | E-GEOD-27678 | biostudies-arrayexpress
TranscriptomicsMapping the cellular and molecular landscape of cardiac non-myocytes in murine type-2 diabetes
Here we define key single-cell transcriptional alterations within cardiac non-myocytes, from ventricles of spontaneously type-2 diabetic (db/db) and control (db/h) mouse hearts ([B6.BKS(D)-Lepr/J], stock #000697). The cell preparation sequenced consisted of metabolically active, live and nucleat...
ORGANISM(S): Mus musculus 
2022-11-29 | E-MTAB-11940 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of F344/N rats administered with potassium bromate in the drinking water
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms b...
ORGANISM(S): Rattus norvegicus 
2006-11-14 | E-TOXM-21 | biostudies-arrayexpress
TranscriptomicsSequence discrimination study
The use of DNA microarrays to identify nucleotide variation is almost 20 years old. A variety of improvements in probe design and experimental conditions have brought this technology to the point that single-nucleotide differences can be efficiently detected in unmixed samples, although developing r...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-19319 | biostudies-arrayexpress
TranscriptomicsSall4 ChIP-chip in mouse ES cell line W4 using NimbleGen MM8 RefSeq Promoter array (2.5kb)
Embryonic stem cells have potential utility in regenerative medicine due to their pluripotent characteristics. Sall4, a zinc-finger transcription factor, is expressed very early in embryonic development with Oct4 and Nanog, two well characterized pluripotency regulators. Sall4 plays an important rol...
ORGANISM(S): Mus musculus 
2008-09-01 | E-GEOD-11305 | biostudies-arrayexpress
UnknownModeling the energy consumption of potable water reuse schemes.
Not available
S-EPMC8640112 | biostudies-literature
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