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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownFrequent Undetected Ward-Based Methicillin-Resistant Staphylococcus aureus Transmission Linked to Patient Sharing Between Hospitals.
Not available
S-EPMC5850096 | biostudies-literature
UnknownThe hyaluronic acid capsule of Streptococcus uberis is not required for the development of infection and clinical mastitis.
Not available
S-EPMC143150 | biostudies-literature
UnknownLong-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study.
Not available
S-EPMC9297673 | biostudies-literature
UnknownGeospatial Variation in Vaccination Coverage and Zero-Dose Prevalence at the District, Ward and Health Facility Levels Before and After a Measles Vaccination Campaign in Nigeria.
Not available
S-EPMC11680329 | biostudies-literature
UnknownJasmonic acid contributes to rice resistance against Magnaporthe oryzae.
Not available
S-EPMC9764487 | biostudies-literature
UnknownA Randomized Controlled Trial of Combinatorial Pharmacogenetics Testing in Adolescent Depression.
Not available
S-EPMC9118122 | biostudies-literature
UnknownCentral mechanisms of odour object perception.
Not available
S-EPMC3722866 | biostudies-literature
ProteomicsRe-evaluation of the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: CIAPIN1 is a major target of VLX1570 for non-selective covalent modification and aggregation in a multiple myeloma model.
Deubiquitinating enzymes are a growing target class across multiple disease states, with several inhibitors now reported. b-AP15 and VLX1570 are two structurally related USP14/UCH-37 inhibitors. Initially taken forward into a phase I/II clinical trial for refractory Multiple Myeloma, VLX1570 has sin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015412 | Pride
Proteomics Vlx1570 Chemoproteomics Bap-15 Multiple myeloma 
ProteomicsA Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in cellular studies. Our collection provides inhib...
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD009028 | Pride
Lfq Epigenetics Chemical probes 
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