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ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
ProteomicsMolecular basis of vitamin K driven γ-carboxylation at membrane interface
The γ-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for h...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD059315 | Pride
Human Electron microscopy Cryo-em Post-translational modifications Lc-ms/ms 
UnknownHigh Temperature Evaporation and Isotopic Fractionation of K and Cu.
Not available
S-EPMC8740699 | biostudies-literature
MetabolomicsAn ancient residue metabolomics-based method to distinguish use of closely related plant species in ancient pipes

Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarke...

2020-07-21 | MTBLS890 | MetaboLights
GenomicsAstrocyte Deletion of alpha2-Na/K ATPase Triggers Episodic Motor Paralysis in Mice via a Metabolic Pathway
Astrocyte Deletion of alpha2-Na/K ATPase Triggers Episodic Motor Paralysis in Mice via a Metabolic Pathway
PRJNA606043 | ENA
UnknownThe ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.
Not available
S-EPMC2937067 | biostudies-literature
UnknownA hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle.
Not available
S-EPMC3108363 | biostudies-literature
UnknownCost Analysis of Implementing a 12-Month Recertification Criterion for Ryan White HIV/AIDS Program's AIDS Drug Assistance Program in Washington State.
Not available
S-EPMC11344975 | biostudies-literature
GenomicsHistone H2B^3-32, H2B K->G, H2B^3-37, and H2B^30-37 mutations
Histone H2B^3-32, H2B K->G, H2B^3-37, and H2B^30-37 mutations
PRJNA94007 | ENA
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