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MetabolomicsCesarean section-induced changes in the gut microbiota facilitate metabolic disease in high-fat diet-induced obese mice

Growing evidence suggests that CS birth may alter the gut microbiota (i.e. dysbiosis), increasing the risk of immune and metabolic disorders. This study aims to investigate the causal relationship between caesarean section (CS)-induced gut dysbiosis and obesity in a high-fat diet mouse model. In ...

2026-02-03 | MTBLS13792 | MetaboLights
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
TranscriptomicsEffects of elevated seawater pCO2 on gene expression patterns in the gills of the green crab, Carcinus maenas
In order to promote our understanding of the responses of green crab acid-base regulatory epithelia to high pCO2, Baltic Sea green crabs were exposed to a pCO2 of 400 Pa for 3 and 7 days after which posterior gills 7 and 9 were sampled. Gills were then subsequently screened for differentially expres...
ORGANISM(S): Carcinus maenas 
2011-10-09 | E-GEOD-28870 | biostudies-arrayexpress
ProteomicsTranscriptome, proteome, and metabolome of lens fiber cells from mice exposed to cigarette smoke
We adopted an omics (transcriptome, proteome, and metabolome) approach to characterize the lens fiber cells extracted from control (CT) and cigarette smoke (CS) exposed mouse (C57BL/6) eyes. The eight pregnant female mice (gestation days 19-20) were placed in a whole-body exposure smoking chamber an...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD017414 | Pride
Mouse Metabolome Mass spectromtery Proteome Transcriptome 
ProteomicsTranscriptome, proteome, and metabolome of lens fiber cells from mice exposed to cigarette smoke
We adopted an omics (transcriptome, proteome, and metabolome) approach to characterize the lens fiber cells extracted from control (CT) and cigarette smoke (CS) exposed mouse (C57BL/6) eyes. The eight pregnant female mice (gestation days 19-20) were placed in a whole-body exposure smoking chamber an...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020421 | Pride
Mass-spectrometry Mouse lens fiber cells Tmt Proteome Cigarette smoke 
UnknownFirst Toxicological Analysis of the Pufferfish Sphoeroides pachygaster Collected in Italian Waters (Strait of Sicily): Role of Citizens Science in Monitoring Toxic Marine Species.
Not available
S-EPMC10252100 | biostudies-literature
ProteomicsRevealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange mass spectrometry
CysE and CysK, the last two enzymes of the cysteine biosynthetic pathway, engage in a bienzyme complex, cysteine synthase (CS), with yet incompletely characterized three-dimensional structure and regulatory function. Being absent in mammals, the two enzymes and their complex are attractive targets f...
ORGANISM(S): Escherichia coli 
2021-06-07 | PXD025300 | Pride
Cysteine biosynthesis Allosteric regulation E. coli Synapt g2-si Bienzyme complex Hydrogen deuterium exchange (hdx-ms) Protein-protein interactions Cysteine synthase 
ProteomicsBering Strait surface water and Chukchi Sea bottom water microbiome metaproteomics
Analysis of bacterial fraction collected on GF/F filters post pre-filtration on 1um filter. 15L were filtered from Bering Strait (BSt) surface water and Chukchi Sea (station 2) bottom waters.
ORGANISM(S): marine metagenome 
2019-01-25 | PXD006472 | Pride
Bering strait surface water and chukchi sea bottom water microbiome metaproteomics 
ProteomicsMechanisms of microbial magnetite oxidation by Sideroxydans lithotrophicus ES-1
Iron-oxidizing bacteria are widely found in natural and man-made environments where they influence varied biogeochemical cycles. Despite their prevalence, the mechanisms and Fe(II) substrates used by these organisms remain understudied. To date, there has been limited exploration of the ability of i...
ORGANISM(S): Sideroxydans Lithotrophicus (ncbitaxon:63745) 
2024-01-04 | MSV000093770 | MassIVE
MetabolomicsAlterations in fecal metagenomics and serum metabolomics indicate management strategies for patients with Budd-Chiari syndrome

OBJECTIVES: We investigated the effects of gut microbiota and serum metabolic levels on the patients with Budd-Chiari syndrome (B-CS), and their guidance for clinical management strategies.

DESIGN: 214 B-CS subjects including untreated case (n=93) and treat...

2021-10-20 | MTBLS2319 | MetaboLights
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