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MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
ProteomicsCSF levels of Elongation Factor Tu is associated with increased mortality in human Streptococcus pneumoniae meningitis
Background Mortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae, exceeds 50% in low and middle income countries in sub-Saharan Africa with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host and pathogen proteome in a...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD021268 | Pride
Cerebrospinal fluid Proteomics Hiv Mortality Streptococcus pneumoniae 
MetabolomicsMulti-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foo...
2020-11-19 | MTBLS138 | MetaboLights
MetabolomicsIntegrating genomics and multi‐platform metabolomics enables metabolite QTL detection in breeding‐relevant apple germplasm
Apple (Malus × domestica) has commercial and nutritional value, but breeding constraints of tree crops limit varietal improvement. Marker-assisted selection minimizes these drawbacks, but breeders lack applications for targeting fruit phytochemicals. To understand genotype-phytochemical associations...
2021-09-21 | MTBLS2327 | MetaboLights
UnknownN-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.
Not available
S-EPMC10313170 | biostudies-literature
UnknownRituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey.
Not available
S-EPMC10432325 | biostudies-literature
ProteomicsProteomic changes following knockdown of DNA repair and redox signaling protein, APE1/Ref-1, under hypoxia conditions
Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy and understanding disease progression. Redox factor...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020515 | Pride
Transcription factor signaling Ape1/ref-1 Dna repair Pancreatic cancer Hypoxia 
ProteomicsTumor tissue collection and processing under physioxia allows highly relevant detection of signaling networks and drug sensitivity of cancer cells
Preclinical studies of primary cancer cells are always done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However, O2 concentrations in organs are in the ~3-10% range, with most tumors in an hypoxic or 1-2% O2 environment in vivo. Although effects of O2 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023133 | Pride
Mouse Tumor Lc-ms/ms 
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. The majority of preclinical studies, including our own, on cancer-induced skeletal mus...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034000 | Pride
Breast cancer Muscle stem cells Skeletal muscle Lc-msms. Mir-486 Cancer cell line Human Biomarker 
ProteomicsFunctional Response of Polar Bacterial Communities under Variable Organic Inputs Revealed with Metaproteomic, 16S rRNA and Organic Compositional Analysis
Organic matter recycling in marine systems is largely driven by microbial processes, particularly in the Arctic where primary production and inputs can be temporally offset from upper trophic level consumption. This study followed bacterial dynamics in the chlorophyll maximum of the Bering Strait an...
ORGANISM(S): marine metagenome 
2019-02-18 | PXD008780 | Pride
Metaproteomics Metagenomics Bacteria Arctic Organic matter 
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