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TranscriptomicsAntibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)
We sought to investigate the extent of genetic and antigen-driven predetermination of antibody repertoires throughout B-cell development (pre-B cells, naive B cells, plasma cells). To this end, we used (i) an inbred model organism (mouse, C57BL/6J) to quantify genetic predetermination and (ii) cohor...
ORGANISM(S): Mus musculus 
2017-03-28 | E-MTAB-5349 | biostudies-arrayexpress
TranscriptomicsPost-ovulatory aging effects on Atlantic halibut (Hippoglossus hippoglossus) egg transcriptome across developmental stages
RNA-seq analysis examining the effects of post-ovulatory aging on gene expression in Atlantic halibut (Hippoglossus hippoglossus) eggs. Eggs from one female were stored at 6°C for 0, 1, 2, 4, 6, or 12 hours before fertilization (t0-t12). RNA was extracted from four developmental stages: unfertilized...
ORGANISM(S): Hippoglossus hippoglossus 
2026-01-30 | E-MTAB-16068 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HEK293T control and ZAP-L or ZAP-S isoform knockout cells mock infected or infected with wild type HIV-1 or CpG-recoded HIV-1
The zinc finger antiviral protein (ZAP, also known as PARP13 or ZC3HAV1) is an antiviral factor that restricts the replication of a wide range of RNA and DNA viruses. It exerts its antiviral function primarily by binding specific sequences known as ZAP response elements (ZREs) within single-stranded...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15061 | biostudies-arrayexpress
TranscriptomicsA comparison of DNA copy number profiling platforms using a panel of melanoma cell lines
The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor suppressor genes and oncogenes. Microarray-based assays designed to detect these chromosomal copy number alterations on a genome-wide and high-resolu...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7822 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA copy number predictors of lapatinib sensitivity in tumour-derived cell lines
A common aim of pharmacogenomic studies that employ genome-wide assays on panels of cancers is the unbiased discovery of genomic alterations that are associated with clinical outcome and drug response. Previous investigations of lapatinib, a selective dual-kinase inhibitor of EGFR and HER2 tyrosine...
ORGANISM(S): Homo sapiens 
2008-03-10 | E-GEOD-9585 | biostudies-arrayexpress
TranscriptomicsIdentification of beta-catenin-associated RNAs in myeloid leukaemia cells through RIP-seq
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood lymphocytes: comparison between melanoma patients and healthy controls
We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC s...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6887 | biostudies-arrayexpress
TranscriptomicsDowling-Meara experiment 2
Dowling-Meara type epidermolysis bullosa simplex (EBS-DM) is a severe blistering disease, caused by dominant mutations in either the keratin-5 (K5) or keratin-14 (K14) gene. K5 and K14 are the major components of the intermediate filament (IF) network in basal keratinocytes. Due to the dominant natu...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-MTAB-1641 | biostudies-arrayexpress
TranscriptomicsGene expression analyses of mice selectively inbred for trait anxiety
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-05-04 | E-GEOD-29015 | biostudies-arrayexpress
UnknownIgA+ memory B-cells are significantly increased in patients with asthma and small airway dysfunction.
Not available
S-EPMC9630610 | biostudies-literature
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